Prevalence of depression and depressive symptoms in patients with systemic lupus erythematosus: Iranian experience

  title={Prevalence of depression and depressive symptoms in patients with systemic lupus erythematosus: Iranian experience},
  author={Zahra Zakeri and Mansoor Shakiba and Behzad Narouie and Nikol Mladkova and Mohammad Ghasemi-rad and Alireza Khosravi},
  journal={Rheumatology International},
Psychiatric disorders including depression represent clinical manifestation of systemic lupus erythematosus (SLE). Recognition of depression in SLE patients is of utmost importance since it is treatable and can be of fatal consequences if unrecognized. This study was conducted to determine the prevalence of depression and depressive symptoms in SLE patients in terms of age, gender, disease duration and severity, and duration of steroid treatment in SLE patients. Eighty-five SLE patients (77… 

Depression in Patients with Systemic Lupus Erythematosus: A Multicenter Study

The study results revealed high prevalence of depression among Saudi patients with SLE and most of the study population were not adequately treated, suggesting inadequate recognition and treatment of depression in SLE.

Prevalence and severity of depression and anxiety in patients with systemic lupus erythematosus: An epidemiologic study in Iranian patients

This study indicated the high prevalence of depression and anxiety among SLE patients and reinforced the need of a comprehensive psychiatric work-up in SLE.

Gender differences in systemic lupus erythematosus concerning anxiety, depression and quality of life

Significant gender differences are observed regarding the prevalence of depressive and anxiety symptoms in patients with SLE, with significantly higher values in the female group, and the presence of these symptoms appears to have a negative effect on the QOL of patients of both genders.

Prevalence and correlates of suicidal thoughts in patients with neuropsychiatric lupus

In patients with suicidal ideation the prevalence of cognitive, psychiatric and neurological self-perceived problems was significantly higher and Neuropsychiatric manifestation per se, depression, anxiety and patients’ subjective complaints can be risk factors for suicidal Ideation.

Evaluation of depression and general health assessment among systemic lupus erythematosus patients in relation to disease activity and damage

Depression and psychological distress were both common in SLE patients and depression severity was linked to illness duration, activity, and damage.

Psychological distress in corticosteroid-naive patients with systemic lupus erythematosus: A prospective cross-sectional study

Depression presents more frequently in corticosteroid-naive patients with early-stage, active SLE than in the normal population, but anxiety does not, indicating that depression may be related to psychological reactions to suffering from the disease.

Prevalence and predictors of depression in patients with systemic lupus erythematosus: a cross-sectional study

The findings suggest that depression and anxiety are common in SLE patients and in addition, higher levels of anxiety and a younger age may increase the risk of depression.

Could ICD10 reflect the effect of Anxiety and Depression on Systemic Lupus Erythematosus Disease Burden?

Psychiatric manifestations are common in SLE, and they positively correlated with the disease activity, and using ICD-10 as a standardized tool for assessment of anxiety and depression in Sle patients is valuable for future comparisons with other studies on SLE patients.


Doctors across all specialties involved in the care for lupus patients should be aware of the major prevalence of this condition, while helping patients to cope with their disabling disease, and take a multidisciplinary approach to improve early detection of depression.



Psychiatric symptoms in systemic lupus erythematosus: an update.

  • E. Wekking
  • Psychology, Medicine
    Psychosomatic medicine
  • 1993
There was no consistent relationship between the occurrence of psychiatric symptoms and other symptoms of SLE, and there is some evidence, however, indicating that a small proportion of the psychiatric symptomatology, in particular psychosis, is related to neurological dysfunction in SLE.

Prevalence of mood and anxiety disorders in women with systemic lupus erythematosus.

Several mood and anxiety disorders were more common in women with SLE compared with the general population, and disease activity may contribute to this higher risk.

Prediction of depression in systemic lupus erythematosus patients using SF-36 Mental Health scores.

The present study contributes to knowledge of means of excluding depression and the prevention of underdiagnosis and undertreatment of depression in SLE patients.

Major depressive disorder and disease activity in systemic lupus erythematosus.

Screening for Depression in Systemic Lupus Erythematosus with the British Columbia Major Depression Inventory

Self-reported symptoms in patients with SLE and community control subjects were examined with the British Columbia Major Depression Inventory and the Beck Depression Inventory–II and a subset of patients with depression, according to the Beck inventory, were selected.

Psychiatric disorder and cognitive impairment in systemic lupus erythematosus.

The point prevalence of psychiatric disorder in this cohort of patients with SLE was found to be similar to that observed in patients with rheumatoid arthritis, and was independently associated with social stress and 2 indicators of cognitive impairment, but not with systemic disease activity or corticosteroid therapy.

[Psychiatric disorders in rheumatic diseases, as exemplified by systemic lupus erythematosus (SLE)].

  • M. Haupt
  • Psychology, Medicine
    Zeitschrift fur Rheumatologie
  • 2004
Among the rheumatic diseases, systemic lupus erythematosus (SLE) reveals the highest frequency of central nervous symptoms. Psychiatric abnormalities are present in over 90% of the patients, if very

Prevalence of depressive and anxiety disorders in systemic lupus erythematosus and their association with anti-ribosomal P antibodies

  • F. NeryE. Borba F. L. Neto
  • Medicine, Psychology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2008

Psychiatric morbidity in patients with systemic lupus erythematosus.

The patients with psychiatric disorders were similar to those who had no psychopathology with respect to age, sex, duration of illness, lupus activity and the use of steroids, however, they had experienced more stressful life events in the last year.

Depression, fatigue, and pain in systemic lupus erythematosus (SLE): relationship to the American College of Rheumatology SLE neuropsychological battery.

Overall, results suggest that cognitive dysfunction, pain, fatigue, and depression in patients with NPSLE may represent global changes in the central nervous system that require ongoing evaluation and treatment.