Prevalence of debrisoquine oxidation phenotypes in glaucoma patients

@article{Salminen2005PrevalenceOD,
  title={Prevalence of debrisoquine oxidation phenotypes in glaucoma patients},
  author={L. Salminen and R. Lindberg and H. -. Toivari and R. Huupponen and T. Kaila and E. Iisalo},
  journal={International Ophthalmology},
  year={2005},
  volume={13},
  pages={91-93}
}
The oxidation of debrisoquine, a sympatholytic antihypertensive agent, exhibits genetic polymorphism. The debrisoquine/4-OH-debrisoquine metabolic ratio (MR) separates the population to poor (PM, MR>12.6) and extensive (EM, MR<12.6) metabolizers. 5–10% of the caucasians belong to the PM phenotype. The oxidation of many other drugs, like timolol, correlates with the debrisoquine phenotype.We determined the debrisoquine phenotype in 102 glaucoma patients. The majority of the patients was treated… Expand
2 Citations
Ethnic Differences in the Systemic Pharmacology for Ophthalmologists
TLDR
It is helpful to remember the differences in efficacy or side effects based on ethnicity when considering the utilization of medications used in ophthalmology. Expand

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