Prevalence of darunavir resistance-associated mutations: patterns of occurrence and association with past treatment.

@article{Mitsuya2007PrevalenceOD,
  title={Prevalence of darunavir resistance-associated mutations: patterns of occurrence and association with past treatment.},
  author={Yumi Mitsuya and Tommy F. Liu and Soo-Yon Rhee and Walford Jeffrey Fessel and Robert W. Shafer},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={196 8},
  pages={1177-9}
}
Eleven protease mutations have been associated with reduced susceptibility to darunavir (DRV). We examined the prevalence and covariates of these mutations in 2 populations. Thirty percent of 1175 Northern California patients and 24% of 2744 non-California patients in the Stanford HIV Drug Resistance Database had viruses with 1 or more mutations associated with resistance to DRV. In multivariate analyses, the number of DRV resistance-associated mutations depended on the number of previous… CONTINUE READING

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