Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study.

  title={Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study.},
  author={Alessio Fasano and Irene Berti and Tania Gerarduzzi and Tarcisio Not and Richard B. Colletti and Sandro Drago and Yoram Elitsur and Peter H. R. Green and Stefano Guandalini and Ivor D. Hill and Michelle M Pietzak and Alessandro Ventura and M A Thorpe and Deborah Kryszak and Fabiola Fornaroli and Steven S. Wasserman and Joseph A. Murray and K{\'a}roly Horv{\'a}th},
  journal={Archives of internal medicine},
  volume={163 3},
BACKGROUND Celiac disease (CD) is an immune-mediated enteropathic condition triggered in genetically susceptible individuals by the ingestion of gluten. Although common in Europe, CD is thought to be rare in the United States, where there are no large epidemiologic studies of its prevalence. The aim of this study was to determine the prevalence of CD in at-risk and not-at-risk groups in the United States. METHODS Serum antigliadin antibodies and anti-endomysial antibodies (EMA) were measured… 

Tables from this paper

Screening for Celiac Disease in a Pediatric Primary Care Setting

The results suggest that the prevalence of CD in children approximates that of US adults and that the true prevalence in children without known risk factors may be increasing.

Predictors of family risk for celiac disease: a population-based study.

  • A. Rubio-TapiaC. V. van Dyke J. Murray
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2008

[Increased prevalence of celiac disease in first and second-grade relatives. A report of a family with 19 studied members].

It is seen that family studies are needed every time a patient is diagnosed with celiac disease; these studies should include both first- and second-degree relatives, given the high prevalence encountered and the fact that these tests are relatively straighforward to perform.

The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review.

Clinicians in a variety of specialties should have a high index of suspicion for the diagnosis of CD and in particular need to pay close attention to the identified high-risk groups.

IgA anti-transglutaminase antibodies as a tool for screening atypical forms of coeliac disease in a French at-risk paediatric population

Children displaying minimal symptoms frequently associated with coeliac disease and children with DM1 should be systematically screened for tTG Abs, which was detected in 2.6% of children with symptoms associated with CD, such as digestive signs and growth failure.

Prevalence of Celiac Disease Among First-degree Relatives of Patients With Celiac Disease

The present study identified 23 undiagnosed cases of celiac disease among 484 first-degree relatives of 195 patients with Celiac disease, confirming the high prevalence (4.8%) of the disease in this specific group.

[Celiac disease: diagnosis prevalence in a community hospital].

In a primary care HMO setting, using secondary databases from EMR, the authors found 1 case of celiac disease every 470 affiliates, giving a prevalence of 0.22%, which could be considered relatively high.

Screening for Celiac Disease in a North American Population: Sequential Serology and Gastrointestinal Symptoms

Serologic testing can readily detect this disease in a general population of a geographically isolated area and screening for celiac disease was widely accepted in this preventative health-care setting.

Utility of the New ESPGHAN Criteria for the Diagnosis of Celiac Disease in At-risk Groups

Strong positive RBC-TG2ab showed good accuracy and excellent correlation with the other antibodies and celiac-type human leukocyte antigen, and the diagnosis of celiac disease was established in 94% of both children and adults.

Celiac disease in children.




Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease.

The data show for the first time that the prevalence of autoimmune disorders in celiac disease is related to the duration of exposure to gluten.

High prevalence of asymptomatic coeliac disease in Norway: a study of blood donors.

The study indicates a prevalence of latent coeliac disease in apparently healthy Norwegian individuals of 1:340 among asymptomatic and presumably healthy people, in keeping with studies from other countries.

The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school‐age subjects

These findings confirm that, in Italy, CD is one of the most common chronic disorders showing a wide and heterogeneous clinical spectrum and most CD cases remain undiagnosed unless actively searched.

Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum.

The current gold standard for the diagnosis of CD remains histologic confirmation of the intestinal damage in serologically positive individuals, and the keystone treatment of CD patients is a lifelong elimination diet in which food products containing gluten are avoided.

Undiagnosed coeliac disease is common in Finnish adults.

Undiagnosed coeliac disease is common in the adult population in Finland; in this study the prevalence was 1 in 130; Screening for coelcream disease is recommended on minor suspicion.

[Prevalence of celiac disease in patients with chronic diarrhea].

Investigation of biopsy materials of the small intestine and levels of antibodies to alpha-gliadin of class A immunoglobulins (IgA) and tissue transglutaminase found that patients with the latent form of the disease prevail among patients with celiac disease.

Characteristics of adult celiac disease in the USA: results of a national survey

Patients with celiac disease in the United States have a long duration of symptoms and consider their diagnosis delayed, and improved quality of life after diagnosis is common, with an increased risk of developing small intestine malignancies.

Genes and environment in celiac disease

Results point to control of the immune response to gluten by intestinal T cells restricted by the DQ2 or DQ8 molecules, likely to be a critical checkpoint for the development of celiac disease.

Coeliac disease in the year 2000: exploring the iceberg