Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study.

@article{Fasano2003PrevalenceOC,
  title={Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study.},
  author={Alessio Fasano and Irene Berti and Tania Gerarduzzi and Tarcisio Not and Richard B. Colletti and Sandro Drago and Yoram Elitsur and Peter H. R. Green and Stefano Guandalini and Ivor D. Hill and Michelle M Pietzak and Alessandro Ventura and M A Thorpe and Deborah Kryszak and Fabiola Fornaroli and Steven S. Wasserman and Joseph A. Murray and K{\'a}roly Horv{\'a}th},
  journal={Archives of internal medicine},
  year={2003},
  volume={163 3},
  pages={
          286-92
        }
}
BACKGROUND Celiac disease (CD) is an immune-mediated enteropathic condition triggered in genetically susceptible individuals by the ingestion of gluten. Although common in Europe, CD is thought to be rare in the United States, where there are no large epidemiologic studies of its prevalence. The aim of this study was to determine the prevalence of CD in at-risk and not-at-risk groups in the United States. METHODS Serum antigliadin antibodies and anti-endomysial antibodies (EMA) were measured… Expand
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References

SHOWING 1-10 OF 39 REFERENCES
The prevalence of celiac disease in at-risk groups of children in the United States.
TLDR
CD is not rare in the United States and may be as common as in Europe, and AGA and EMA are useful for identifying patients who should undergo a small intestinal biopsy. Expand
Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease.
TLDR
The data show for the first time that the prevalence of autoimmune disorders in celiac disease is related to the duration of exposure to gluten. Expand
Prevalence of celiac disease among blood donors in Brazil
TLDR
The preliminary results support the view that CD is not a rare disease in Brazil, with a prevalence of undiagnosed CD of 1:681 among apparently healthy blood donors. Expand
High prevalence of asymptomatic coeliac disease in Norway: a study of blood donors.
TLDR
The study indicates a prevalence of latent coeliac disease in apparently healthy Norwegian individuals of 1:340 among asymptomatic and presumably healthy people, in keeping with studies from other countries. Expand
The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school‐age subjects
TLDR
These findings confirm that, in Italy, CD is one of the most common chronic disorders showing a wide and heterogeneous clinical spectrum and most CD cases remain undiagnosed unless actively searched. Expand
Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum.
TLDR
The current gold standard for the diagnosis of CD remains histologic confirmation of the intestinal damage in serologically positive individuals, and the keystone treatment of CD patients is a lifelong elimination diet in which food products containing gluten are avoided. Expand
Celiac disease risk in the USA: high prevalence of antiendomysium antibodies in healthy blood donors.
TLDR
The prevalence of increased AEA levels in healthy blood donors in the USA is 1:250, similar to that reported in countries in Europe, where subsequent small-intestinal biopsies have confirmed CD in all those with AEA positivity. Expand
Undiagnosed coeliac disease is common in Finnish adults.
TLDR
Undiagnosed coeliac disease is common in the adult population in Finland; in this study the prevalence was 1 in 130; Screening for coelcream disease is recommended on minor suspicion. Expand
[Prevalence of celiac disease in patients with chronic diarrhea].
TLDR
Investigation of biopsy materials of the small intestine and levels of antibodies to alpha-gliadin of class A immunoglobulins (IgA) and tissue transglutaminase found that patients with the latent form of the disease prevail among patients with celiac disease. Expand
Characteristics of adult celiac disease in the USA: results of a national survey
TLDR
Patients with celiac disease in the United States have a long duration of symptoms and consider their diagnosis delayed, and improved quality of life after diagnosis is common, with an increased risk of developing small intestine malignancies. Expand
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