Prevalence of antimalarial drug resistance mutations in Plasmodium vivax and P. falciparum from a malaria-endemic area of Pakistan.

@article{Khatoon2009PrevalenceOA,
  title={Prevalence of antimalarial drug resistance mutations in Plasmodium vivax and P. falciparum from a malaria-endemic area of Pakistan.},
  author={Lubna Khatoon and Frederick N. Baliraine and Mariangela Bonizzoni and Salman A. Malik and Guiyun Yan},
  journal={The American journal of tropical medicine and hygiene},
  year={2009},
  volume={81 3},
  pages={525-8}
}
To study drug resistance in Bannu district, a malaria-endemic area in Pakistan, molecular-based analyses were undertaken. In Plasmodium vivax, antifolate resistance mutations were detected in pvdhfr gene codons 57, 58, and 117, with a 117N mutation frequency of 93.5%. All P. falciparum isolates exhibited double 59R + 108N mutations in pfdhfr, whereas the triple mutant 59R + 108N + 437G haplotype was found in 31.8% isolates. Furthermore, all (100%) P. falciparum isolates exhibited the key… CONTINUE READING

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