Prevalence of and risk factors for resistance to second-line drugs in people with multidrug-resistant tuberculosis in eight countries: a prospective cohort study

@article{Dalton2012PrevalenceOA,
  title={Prevalence of and risk factors for resistance to second-line drugs in people with multidrug-resistant tuberculosis in eight countries: a prospective cohort study},
  author={Tracy L. Dalton and Peter Cegielski and Somsak Akksilp and Luis Asencios and Janice Campos Caoili and Sang-Nae Cho and Vladislav V Erokhin and Julia V. Ershova and Maria Tarcela Gler and Boris Y. Kazennyy and Hee Jin Kim and Kai Kliiman and E V Kurbatova and Charlotte Kvasnovsky and Vaira Leimane and Martie van der Walt and Laura E. Via and Grigory Volchenkov and Martin J. A. Yagui and Hyungseok Kang},
  journal={The Lancet},
  year={2012},
  volume={380},
  pages={1406-1417}
}

Tables from this paper

Low Levels of Extensively Drug-resistant Tuberculosis among Multidrug Resistant Tuberculosis Isolates and Their Relationship to Risk Factors: Surveillance in Tehran, Iran; 2006 to 2014

TLDR
A greater understanding is provided of the evolution and spread of M/XDR-TB in an environment where drug-resistant TB has a low incidence and strategies must be implemented to identify and cure patients with pre-Xdr-TB before they develop XDR- TB.

Pattern of resistance to second line anti-tuberculosis drugs and associated risk factors among multidrug-resistant patients of pulmonary tuberculosis from Agra region of Uttar Pradesh, North India

Present study was aimed to determine the status of second-line anti-TB drug resistance and risk factorsfor extensively drug-resistance (XDR)-tuberculosis among multi-drug resistant (MDR)-tuberculosis

Multidrug-Resistant Tuberculosis Treatment Outcomes in Relation to Treatment and Initial Versus Acquired Second-Line Drug Resistance.

TLDR
Increasing drug resistance was associated in a logical stepwise manner with poor treatment outcomes and acquired resistance was worse than initial resistance to the same drugs.

Extensive drug resistance acquired during treatment of multidrug-resistant tuberculosis.

TLDR
Treatment of MDR tuberculosis involves substantial risk of acquired resistance to SLDs, increasing as baseline drug resistance increases, and the risk was significantly lower in programs documented by the GLC to meet specific standards.

Implications of Failure to Routinely Diagnose Resistance to Second-Line Drugs in Patients With Rifampicin-Resistant Tuberculosis on Xpert MTB/RIF: A Multisite Observational Study

  • K. JacobsonM. Barnard R. Warren
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2017
TLDR
Many South Africans diagnosed with RR-tuberculosis by Xpert initiate a suboptimal regimen, with information to adjust therapy available in half of all patients after a median 7 weeks.

[Resistance to second-line drugs in migrants with multidrug-resistant tuberculosis in the Berlin region].

TLDR
The regional differences in mycobacterial susceptibility to second line drugs suggest that the initial MDR TB therapy of migrants should be tailored to their country of origin.

Direct observation therapy with appropriate treatment regimens was associated with a decline in second-line drug-resistant tuberculosis in Taiwan

TLDR
A retrospective analysis of resistance profiles among MTB isolates obtained from 6,035 consecutive patients from 2004 to 2011 at two TB referral hospitals in Taiwan found the implementation of DOTS/DOTS-plus programs with appropriate regimens was associated with a decrease in the prevalence of SLD-resistant and XDR TB.
...

References

SHOWING 1-10 OF 31 REFERENCES

Management of Extensively Drug-Resistant Tuberculosis in Peru: Cure Is Possible

TLDR
A large proportion of XDR-TB patients can be cured if DST to second-line drugs is performed early and treatment is delivered according to the WHO Guidelines, although the overall cure rate was poor.

First- and second-line drug resistance patterns among previously treated tuberculosis patients in India.

  • C. ParamasivanF. Rehman P. R. Narayanan
  • Medicine
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 2010
TLDR
High SLD resistance levels among MDR-TB patients is of concern, and rapid scale-up of quality programmatic management under the RNTCP is needed, with more control and rational use of SLDs outside the programme.

Predictors of Multidrug- and Extensively Drug-Resistant Tuberculosis in a High HIV Prevalence Community

TLDR
Given high mortality observed among patients with HIV and drug-resistant TB co-infection, previously treated and hospitalized patients should be considered for empiric second-line TB therapy while awaiting confirmatory DST results in settings with a high-burden of MDR/XDR-TB.

Risk factors associated with kanamycin-resistant tuberculosis in a Beijing tuberculosis referral hospital.

TLDR
The prevalence of, and risk factors associated with, kanamycin-resistant tuberculosis in 309 Hospital, Beijing, China, is determined with the aim of providing information for better case management and minimize further development of extensively drug-resistant TB (XDR-TB).

Extensively drug-resistant tuberculosis in South Korea: risk factors and treatment outcomes among patients at a tertiary referral hospital.

  • C. JeonSoohee Hwang L. Via
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2008
TLDR
XDR TB was found to be associated with the cumulative duration of previous treatment with second-line TB drugs among subjects in a tertiary care TB hospital, and patients with XDR TB were more likely to not respond to therapy.

Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010.

TLDR
The highest global rates of MDR-TB ever reported were documented in 2009 and 2010, and better surveillance or survey data are required, especially from Africa and India.

Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in iran.

TLDR
The isolation of TDR strains from MDR-TB patients from different regional countries is alarming and underlines the possible dissemination of such strains in Asian countries.

Second-line drug susceptibilities of Thai multidrug-resistant Mycobacterium tuberculosis isolates.

  • T. PrammanananW. Arjratanakool C. Dhiraputra
  • Medicine, Biology
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 2005
TLDR
In this study, DST of 99 MDR-TB strains isolated in Thailand was performed using a drug-impregnated disc method and showed that 94.95% of the strains were susceptible to amikacin and kanamycin, and 78.79% to ethionamide.

Detection of Resistance to Second-Line Antituberculosis Drugs by Use of the Genotype MTBDRsl Assay: a Multicenter Evaluation and Feasibility Study

TLDR
The Genotype MTBDRsl assay presents a good screening tool for the rapid detection of resistance to individual second-line drugs and can be recommended for use in countries with a high burden of MDR/XDR TB.