Prevalence of an immunological LH beta-subunit variant in a UK population of healthy women and women with polycystic ovary syndrome.

@article{Rajkhowa1995PrevalenceOA,
  title={Prevalence of an immunological LH beta-subunit variant in a UK population of healthy women and women with polycystic ovary syndrome.},
  author={M Rajkhowa and James A. Talbot and Paul W. Jones and Kim Pettersson and A M Haavisto and I lpo Huhtaniemi and Richard N. Clayton},
  journal={Clinical endocrinology},
  year={1995},
  volume={43 3},
  pages={297-303}
}
OBJECTIVE An immunological LH beta-subunit variant has been described, which is undetectable using monoclonal antibodies directed to the intact LH molecule alone. Subjects have been found homozygous or heterozygous for nucleotide mutations within codons 8 and 15 in the LH beta-subunit gene. The prevalence of the variant LH beta-subunit has been estimated in a healthy UK population of women of reproductive age and in women with polycystic ovary syndrome (PCOS). The relationship of the variant… CONTINUE READING

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