Prevalence of a plasmid-mediated type II dihydrofolate reductase gene among trimethoprim-resistant urinary pathogens in Greek hospitals.

@article{Tsakris1992PrevalenceOA,
  title={Prevalence of a plasmid-mediated type II dihydrofolate reductase gene among trimethoprim-resistant urinary pathogens in Greek hospitals.},
  author={Athanassios Tsakris and Alkiviadis C. Vatopoulos and Alan P. Johnson and Tyrone Leslie Pitt and N. J. Legakis and Leonidas S. Tzouvelekis},
  journal={The Journal of antimicrobial chemotherapy},
  year={1992},
  volume={29 4},
  pages={405-13}
}
The genetic basis of trimethoprim resistance was examined in 24 Klebsiella pneumoniae, 27 Enterobacter cloacae, five Enterobacter aerogenes and nine Serratia marcescens urinary isolates from five hospitals in Greece. Analysis of the 65 isolates by serotyping and phage-typing identified 53 distinct strains. Thirty-eight isolates (15 K. pneumoniae, 19 E. cloacae, two E. aerogenes and two S. marcescens) hybridized with a probe specific for a gene encoding type II dihydrofolate reductase (DHFR… CONTINUE READING

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