Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection.

@article{Hirschfeld2007PrevalenceOT,
  title={Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection.},
  author={Aaron F. Hirschfeld and Julie A. Bettinger and Rachel E. Victor and Donald J Davidson and Andrew Currie and John Mark Ansermino and DavidW. Scheifele and Jordan S Orange and Stuart E Turvey},
  journal={Clinical immunology},
  year={2007},
  volume={122 3},
  pages={
          271-8
        }
}
Human primary immunodeficiencies affecting Toll-like receptor (TLR) signalling reveal a non-redundant role for TLR function in defense against pneumococcal infection. To determine the clinical relevance of TLR abnormalities, we studied a population predicted to be enriched for TLR defects-healthy children who had developed invasive pneumococcal infection in the absence of classic risk factors for infection. We describe the development and optimization of a peripheral blood TLR assay. By testing… CONTINUE READING
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