Prevalence of Mycobacterium avium subsp. paratuberculosis and Escherichia coli in blood samples from patients with inflammatory bowel disease

@article{Nazareth2015PrevalenceOM,
  title={Prevalence of Mycobacterium avium subsp. paratuberculosis and Escherichia coli in blood samples from patients with inflammatory bowel disease},
  author={Nair Nazareth and Fernando Magro and Elisabete Machado and Teresa Gonçalves Ribeiro and Ant{\'o}nio Martinho and Pedro L. Rodrigues and Rita Alves and Gonçalo Nuno Macedo and Daniela Gr{\'a}cio and Rosa Coelho and C{\^a}ndida F Abreu and Rui Appelberg and Camila H Dias and Guilherme Macedo and Tim John Bull and Am{\'e}lia Sarmento},
  journal={Medical Microbiology and Immunology},
  year={2015},
  volume={204},
  pages={681-692}
}
Mycobacterium avium subsp. paratuberculosis (MAP) and adherent-invasive Escherichia coli (AIEC) have been implicated as primary triggers in Crohn’s disease (CD). In this study, we evaluated the prevalence of MAP and E. coli (EC) DNA in peripheral blood from 202 inflammatory bowel disease (IBD) patients at various disease periods and compared against 24 cirrhotic patients with ascites (CIR) (non-IBD controls) and 29 healthy controls (HC). MAP DNA was detected by IS900-specific nested PCR, EC DNA… CONTINUE READING