Prevalence of Kaposi Sarcoma-Associated Herpesvirus Compared With Selected Sexually Transmitted Diseases in Adolescents and Young Adults in Rural Rakai District, Uganda

@article{Wawer2001PrevalenceOK,
  title={Prevalence of Kaposi Sarcoma-Associated Herpesvirus Compared With Selected Sexually Transmitted Diseases in Adolescents and Young Adults in Rural Rakai District, Uganda},
  author={M J Wawer and Sybil M. Eng and David Serwadda and Nelson K. Sewankambo and Noah Kiwanuka and C Li and Ronald H Gray},
  journal={Sex Transm Dis},
  year={2001},
  volume={28},
  pages={77-81}
}
Background Kaposi sarcoma-associated herpesvirus (KSHV) is transmitted by routes such as homosexual intercourse and is associated with HIV infection in industrialized countries. However, there is little information about its transmission in developing countries where Kaposi sarcoma is an endemic disease. Goal To examine KSHV seroprevalence in young adults in a general, rural Ugandan population, and to compare this prevalence with rates of known sexually transmitted infections. Study Design The… 
Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission.
TLDR
Two distinct relationships between age and KSHV infection among children imply that K SHV transmission among children is not uniform throughout Africa and is therefore not always responsible for the high seroprevalence observed in adults.
Kaposi's Sarcoma Associated-Herpes Virus (KSHV) Seroprevalence in Pregnant Women in South Africa
TLDR
The association between KSHV and HIV seropositivity and a lack of common association with syphilis, suggests that Kaposi's sarcoma-associated herpesvirus transmission may involve geographical and cultural factors other than sexual transmission.
Kaposi's Sarcoma Associated-Herpes Virus (KSHV) Seroprevalence in Pregnant Women in
TLDR
The association between KSHV and HIV seropositivity and a lack of common association with syphilis, suggests that Kaposi’s sarcoma-associated herpesvirus transmission may involve geographical and cultural factors other than sexual transmission.
The epidemiology of Kaposi’s sarcoma associated-herpesvirus in Uganda
TLDR
An investigation of factors that might impact on transmission of Kaposi’s sarcoma associated-herpesvirus (KSHV) and the first prospective study of antibody titre to KSHV to determine risk of KS from Africa are described and reported.
No evidence of sexual transmission of Kaposi's sarcoma herpes virus in a heterosexual South African population
TLDR
The lack of association with high-risk sexual behavior, particularly in sex workers, and with any markers of STI strongly suggest that the sexual mode does not play a significant role in KSHV transmission in this South African population.
Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women
TLDR
Specific parasite infections are associated with presence of antibodies against Kaposi's sarcoma herpesvirus, perhaps mediated via their effect on immune function, and seroprevalence increased with increasing intensity of hookworm infection.
Transmission of Kaposi sarcoma-associated herpesvirus in sub-Saharan Africa.
TLDR
With the HIV epidemic, Kaposi sarcoma has become the commonest cancer in children, women and men in many sub-Saharan African countries and abating this KS epidemic will require concerted efforts to treat individuals with HIV/AIDS and to reduce HIV and KSHV transmission.
Seroprevalence of human herpesvirus 8 infection in Northern Thailand.
  • Nora ChenK. Nelson L. Jacobson
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2004
TLDR
Despite the rarity of KS among patients with AIDS in Thailand, HHV-8 infections are common and do not appear to be frequently transmitted sexually in these populations.
Kaposi Sarcoma–Associated Herpesvirus in a Rural Ugandan Cohort, 1992–2008
TLDR
KSHV seroprevalence and antibodies titers in this rural Ugandan population are the highest yet reported, perhaps reflecting frequent viral reactivation and persistently elevated transmission.
Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda
TLDR
The findings are compatible with the conclusion that sexual transmission of HHV8 in Uganda, if it occurs, is weak.
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References

SHOWING 1-10 OF 20 REFERENCES
Prevalence and transmission of Kaposi's sarcoma‐associated herpesvirus (human herpesvirus 8) in Ugandan children and adolescents
TLDR
Transmission of Kaposi's sarcoma‐associated herpesvirus in Uganda occurs largely before puberty, in contrast to its sexual mode of transmission among homo/bisexual men and sexually transmitted diseases clinic attendees of Northern Europe and the US.
Enhanced detection of human herpesvirus-8 and cytomegalovirus in semen of HIV-seropositive asymptomatic heterosexual men living in Central Africa.
TLDR
Study findings indicate that HHV-8 infection is prevalent in a substantial proportion of the healthy adult population and lend support to the argument that semen could play a role in the sexual transmission of the virus.
The prevalence of serum antibody to human herpesvirus 8 (Kaposi sarcoma-associated herpesvirus) among HIV-seropositive and high-risk HIV-seronegative women.
TLDR
The prevalence of HHV-8 seropositivity among the group of HIV- Infected women was dramatically lower than that recently reported among HIV-infected homosexual and bisexual men and parallels the lower prevalence of Kaposi sarcoma among women in contrast to men with HIV infection.
Serologic evidence of human herpesvirus 8 transmission by homosexual but not heterosexual sex.
TLDR
Among heterosexuals there was no evidence for sexual transmission; the only independent risk factor for HHV-8 seropositivity was birth in Africa and, among homo/bisexual men, a history of syphilis and HSV-2 and human immunodeficiency virus seropposivity.
Seroprevalence of human herpesvirus 8 among Zambian women of childbearing age without Kaposi's sarcoma (KS) and mother-child pairs with KS.
TLDR
There is a high HHV-8 seroprevalence among Zambian women, and the rate is almost the same in HIV-1-positive and -negative women, which may be a contributing factor toward the increased frequency of KS.
KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma
TLDR
Antibody kinetics showed that more than half of the AIDS–KS patients who were examined IgG–seroconverted before KS development, and antibody levels did not decline after seroconversion, suggest that the rate of infection was constant and that the risk of developing KS once infected with KSHV is not highly dependent on the duration of infection.
Human herpesvirus 8 primary infection occurs during childhood in Cameroon, Central Africa
TLDR
The results establish that in Central Africa HHV‐8 infection takes place during childhood by casual routes, in contrast to the sexual transmission observed in adults in northern Europe and the United States.
Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma.
TLDR
In most patients with kaposi's sarcoma and AIDS, seroconversion to positivity for antibodies against KSHV-related nuclear antigens occurs before the clinical appearance of Kaposi's Sarcoma.
Antibodies against human herpesvirus 8 in black South African patients with cancer.
TLDR
Among black patients with cancer in South Africa, the seroprevalence of anti-HHV-8 antibodies is high and is specifically associated with Kaposi's sarcoma, particularly at high titers.
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