Prevalence of Jews as subjects in genetic research: Figures, explanation, and potential implications

  title={Prevalence of Jews as subjects in genetic research: Figures, explanation, and potential implications},
  author={Daphna Birenbaum Carmeli},
  journal={American Journal of Medical Genetics Part A},
  • D. Carmeli
  • Published 15 September 2004
  • Biology
  • American Journal of Medical Genetics Part A
Geneticists' view of ‘population isolates’ as bearing special utility for research often translates into the targeting of such groups as study popuations. This paper aims to outline the prevalence and structure of reference to one such group—that of the Jews—in genetic research publications. The paper uses three prevalence scores, calculated on the basis of a search of the PubMed database, conducted in September–October 2002. A systematic comparison to other population groups shows that in… 
Case studies in the co-production of populations and genetics: The making of ‘at risk populations’ in BRCA genetics
The juxtaposition of the two cases sheds new light on some of the specific cultural and biological practices that produce and define populations in local contexts, highlighting the contrasting ways in which BRCA genetic medicine is developing in relation to population.
Ashkenazi Jews: overburdened and overexposed?
Utilizing a closed-ended survey and three focus groups drawn from one Midwest city, this study examined attitudes of Ashkenazi Jews toward involvement in genetic research. The research is framed
Research populations: biobanks in Israel
Abstract Whereas in many instances the use of ethnic and religious categories as well as assumptions about the proclaimed homogeneity of populations in the context of biobanks have spurred
The Missing Link of Jewish European Ancestry: Contrasting the Rhineland and the Khazarian Hypotheses
  • E. Elhaik
  • History
    Genome biology and evolution
  • 2013
The findings support the Khazarian hypothesis and portray the European Jewish genome as a mosaic of Near Eastern-Caucasus, European, and Semitic ancestries, thereby consolidating previous contradictory reports of Jewish ancestry.
Racial and ethnic disparities in genetic testing for hearing loss: a systematic review and synthesis
The large disparity in the published literature on the genetics of hearing loss is illustrated, and the need for increased representation of Latino American, African, and indigenous North American populations is demonstrated.
Cultural Aspects of Healthy BRCA Carriers From Two Ethnocultural Groups
It is suggested that French Canadian women could benefit from greater awareness of the HBOC genetic risk and that health care providers should consider ethnically related and individual-based experiences and meanings during counseling.
Are Genes Jewish ? Conceptual Ambiguities in the New Genetic Age
The David W. Belin Lectureship in American Jewish Affairs provides an academic forum for the discussion of contemporary Jewish life in the United States. It was established in 1991 through a generous
Geographical Structure of the Y‐chromosomal Genetic Landscape of the Levant: A coastal‐inland contrast
A coastal‐inland, east‐west pattern of diversity and frequency distribution in several haplogroups within the small region of the Levant is found, likely to have arisen mainly from differential migrations, with different lineages introduced from the east and west.
Gene expression and methylation of matrix metalloproteinase-13 and osteoarthritis & Burden of risk alleles for complex traits in the Newfoundland and Labrador population
The results suggest a potential role for MMP-13 in OA pathogenesis and a novel approach to studying disease risk in a population may provide new insights into genetic risk of complex conditions and could be used to inform health policy.
Research with Religious Communities
Much research has been conducted that focuses on specific religious communities; relatively little published literature addresses the conduct of research with religious communities. Engaging in


Founding mothers of Jewish communities: geographically separated Jewish groups were independently founded by very few female ancestors.
The results suggest that most Jewish communities were founded by relatively few women, that the founding process was independent in different geographic areas, and that subsequent genetic input from surrounding populations was limited on the female side.
Population isolates: their special value for locating genes for bipolar disorder.
The rationale for performing gene mapping studies in this type of population and the results of genetic mapping studies performed to date in population isolates are presented.
Experiences in molecular-based prenatal screening for Ashkenazi Jewish genetic diseases.
The Dor Yeshorim story: community-based carrier screening for Tay-Sachs disease.
BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi Jewish women with ovarian cancer.
Only one nonfounder mutation was identified (in this instance, in a woman of mixed ancestry), and the three founding mutations accounted for most of the observed excess risk of ovarian and breast cancer in relatives.
Tay-Sachs disease carrier screening: a 21-year experience.
The findings of a community-based carrier screening program for Tay-Sachs disease, initiated on the University of Wisconsin-Madison campus in 1978, are presented and data on carrier detection with regard to various demographics are presented.
Constructing Ethnicity: Myth of Return and Modes of Exclusion among Israelis in Toronto
Drawing upon data from ninety intensive interviews and from participatory observations of various social gatherings of Israelis living in Toronto, this study explores the role of the desire to return
Critical realism is used to explore the problem of reductionism in a classic (the Amish Study) and wide-cited study of manic depression and concludes by arguing that interactions between behaviors and genes take place only within open systems.
Frequency and carrier risk associated with common BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer patients.
Presymptomatic screening and counseling for these common mutations in Ashkenazi Jewish women not selected for family history of breast cancer should be reconsidered until the risk associated with these mutations is firmly established, since early diagnostic and preventive-treatment modalities are limited.
Participation rates of Ashkenazi Jews in a colon cancer community‐based screening/prevention study
Examination of factors influencing participation and response in a recent colon cancer risk study and strategies for improving participation in future health promotion programs are suggested.