Prevalence of Ile-460-Val/ParE Substitution in Clinical Streptococcus pneumoniae Isolates That Were Less Susceptible to Fluoroquinolones

@article{KawamuraSato2005PrevalenceOI,
  title={Prevalence of Ile-460-Val/ParE Substitution in Clinical Streptococcus pneumoniae Isolates That Were Less Susceptible to Fluoroquinolones},
  author={Kumiko Kawamura-Sato and Tadao Hasegawa and Keizo Torii and Hideo Ito and Michio Ohta},
  journal={Current Microbiology},
  year={2005},
  volume={51},
  pages={27-30}
}
A total of 73 clinical isolates of Streptococcus pneumoniae were measured for susceptibilities to nine fluoroquinolones, and nucleotide sequences of the quinolone resistance-determining regions (QRDRs) were determined. MIC90s of sparfloxacin, tosufloxacin, grepafloxacin, and gatifloxacin were less than 0.5 mg/L and the MIC90 of ciprofloxacin was 2 mg/L, although MIC values of some isolates to ciprofloxacin were more than 2 mg/L. We found that 60 of 73 isolates had only Ile-460-Val/ParE… CONTINUE READING