Prevalence of HSP47 antigen and autoantibodies to HSP47 in the sera of patients with mixed connective tissue disease.

@article{Yokota2003PrevalenceOH,
  title={Prevalence of HSP47 antigen and autoantibodies to HSP47 in the sera of patients with mixed connective tissue disease.},
  author={Shin-Ichi Yokota and Hiroshi Kubota and Yasuhiro Matsuoka and Motoko Naitoh and Daisuke Hirata and Seiji Minota and Hiroki Takahashi and Nobuhiro Fujii and Kazuhiro Nagata},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={303 2},
  pages={413-8}
}
The 47-kDa heat shock protein (HSP47) is an endoplasmic reticulum molecular chaperone that assists in the maturation of collagen molecules and whose expression is known to be upregulated in lesions of fibrotic diseases. We examined the levels of HSP47 protein and autoantibodies to HSP47 in the sera of patients with rheumatic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, and mixed connective tissue disease (MCTD) by enzyme-linked… CONTINUE READING
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