Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients.

Abstract

The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3,129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P<0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16/18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P<0.0001). There was no statistically significant difference in HPV16/18 prevalence in non-oropharyngeal cancer by race (P=0.682). With regard to the pattern of HPV16/18 status and p16 expression, White patients had the highest proportion of HPV16/18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0% and 22.6%, respectively) [P <0.0001]. Our findings suggest that the pattern of HPV16/18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.

DOI: 10.1093/carcin/bgw203

Cite this paper

@article{Ragin2016PrevalenceOH, title={Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients.}, author={Camille C Rose Ragin and Jeffrey C Liu and Gieira Jones and Olubunmi Shoyele and Bukola Sowunmi and Rachel Kennett and Denise Gibbs and Elizabeth Blackman and Michael Esan and Margaret S. Brandwein and Karthik Devarajan and Francesco Bussu and Rebecca D Chernock and C Y Chien and Marc Andrew Cohen and Samir K. El-Mofty and Mikio Suzuki and Gypsyamber D'souza and Pauline Funchain and Charis Eng and Susanne M Gollin and Angela M. Hong and Yuh-S Jung and Maximilian Kr{\"{u}ger and James S Lewis and Patrizia Morbini and Santo Landolfo and Massimo Ritt{\`a} and Jos M J A A Straetmans and Krisztina Szarka and Ruth Tachezy and Francis Paul Worden and Deborah Brooks Nelson and Samuel Gathere and Emanuela Taioli}, journal={Carcinogenesis}, year={2016} }