Prevalence of GAD65 Antibodies in Lean Subjects with Type 2 Diabetes

  title={Prevalence of GAD65 Antibodies in Lean Subjects with Type 2 Diabetes},
  author={Ambika Gopalakrishnan Unnikrishnan and S K Singh and Carani B. Sanjeevi},
  journal={Annals of the New York Academy of Sciences},
Abstract: While type 2 diabetic subjects in developed countries are predominantly obese or overweight, those in India are often nonobese or lean. The reasons for leanness in these subjects has not been well understood. We assessed the prevalence of pancreatic islet autoimmunity in 83 lean adult subjects (BMI < 18.5 kg/m2) with type 2 diabetes by measuring antibodies to glutamic acid decarboxylase‐65 (GAD Abs). Positivity to GAD Ab was present in 21 (25.3%) subjects. In addition, subjects with… 

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