Prevalence of CYP2C8 polymorphisms in a North Indian population.

  title={Prevalence of CYP2C8 polymorphisms in a North Indian population.},
  author={Sachin Minhas and Nitika Setia and Shewata Pandita and R Singh Saxena and Ishwar Chandra Verma and Shyam Aggarwal},
  journal={Genetics and molecular research : GMR},
  volume={12 3},
CYP2C8 is an important member of the cytochrome P450 family of enzymes; it affects the activity of various drugs used in routine clinical practice, including amiodarone, chloroquine, amodiaquine, and repaglinide, as well as endogenous compounds, such as arachidonic acid and retonic acid. It is also the main enzyme involved in the metabolism of the widely used anticancer drug Paclitaxel, which has a very narrow therapeutic index. There is evidence that single nucleotide polymorphisms in the… CONTINUE READING