Prevalence of BRCA1 and BRCA2 germline mutations in patients with triple-negative breast cancer

Abstract

Triple-negative breast cancers (TNBC) lack expression of oestrogen, progesterone and HER2 receptors. The gene expression profiles of TNBCs are similar to those of breast tumours in women with BRCA1 mutations. Reports to date indicate that up to 20 % of TNBC patients harbour germline BRCA mutations; however, the prevalence of BRCA mutations in TNBC patients… (More)
DOI: 10.1007/s10549-015-3293-7

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