Prevalence of 16S rRNA methylase genes in Klebsiella pneumoniae isolates from a Chinese teaching hospital: coexistence of rmtB and armA genes in the same isolate.

@article{Yu2009PrevalenceO1,
  title={Prevalence of 16S rRNA methylase genes in Klebsiella pneumoniae isolates from a Chinese teaching hospital: coexistence of rmtB and armA genes in the same isolate.},
  author={Fang-you Yu and Liangxing Wang and Jingye Pan and Dan Yao and Chan Chen and Tao Zhu and Qiang Lou and Jian Hu and Yang Wu and Xueqing Zhang and Zengqiang Chen and D Q Qu},
  journal={Diagnostic microbiology and infectious disease},
  year={2009},
  volume={64 1},
  pages={57-63}
}
16S rRNA methylase-mediated high-level resistance to aminoglycosides has been reported recently in clinical isolates of Gram-negative bacilli from several countries. Twenty-one (6.2%, 21/337) of 337 isolates of Klebsiella pneumoniae from a teaching hospital in Wenzhou, China, were positive for 16S rRNA methylase genes (3 for armA, 13 for rmtB, 5 for both armA and rmtB) and highly resistant to gentamicin, amikacin, and tobramycin (MICs, > or =256 microg/mL). Nineteen of 21 isolates harboring 16S… CONTINUE READING