Prevalence of β thalassemia carrier state in Sindhi community of Wardha and evaluation of risk factors for β thalassemia trait.

@article{Rakholia2013PrevalenceO,
  title={Prevalence of $\beta$ thalassemia carrier state in Sindhi community of Wardha and evaluation of risk factors for $\beta$ thalassemia trait.},
  author={Ritu Rakholia and Pushpa Chaturvedi},
  journal={Nigerian journal of clinical practice},
  year={2013},
  volume={16 3},
  pages={
          375-80
        }
}
OBJECTIVE To determine the prevalence of β thalassemia in Sindhi community of Wardha and evaluation of risk factors. To give genetic counseling to those diagnosed as carriers. STUDY DESIGN Cross-sectional (prevalence study). SETTING Sindhi community residing in and around Wardha. STUDY PERIOD 18 months. MATERIALS AND METHODS A total of 578 individuals belonging to Sindhi community residing in and around Wardha in India were selected by systemic randomization. Those who fulfilled the… 
View on PubMed
ajol.info
12 Citations
Highly Influential Citations
1
Background Citations
2

12 Citations

Citation Type

Citation Type

PRE-MARITAL SCREENING TESTS OF β-THALASSEMIA TRAIT IN DAKSHINA KANNADA POPULATION OF KARNATAKA
TLDR
The present study shows that the people with β-thalassemia trait have a significant variation in complete hemogram compared to normal; NESTROFT and discriminant functions can be used for the screening of β-Thalassemia traits in the population.
Study of prevalence of hemoglobinopathy in Sindhi community of Jamnagar, Gujarat: A pilot study
TLDR
Sindhi community has a high prevalence of hemoglobinopathy mainly BTT, and mass awareness and community screening of individual and proper counseling should be done to reduce the burden of disease.
Hematological study of iron deficiency anemia and β thalassemia trait in Sindhi community of Bundelkhand region of Madhya Pradesh with predictive value of red cell indices to discriminate them
TLDR
Sindhi community of Sagar district of Madhya Pradesh showed high prevalence of β thalassemia trait and showed high sensitivity and specificity to discriminate iron deficiency anemia from β thAlassemia.
Study of prevalence of haemoglobin disorders in sindhi community with reference to HPLC
TLDR
BTT and Hb Q-India were found to be more common Hb disorders in Sindhi community, and screening of community and counselling regarding the nature of these disorders are very important measures to reduce the burden of disease.
Prevalence of β thalassaemia trait and Haemoglobin E disorders among students aged between 14-17yrs in Kurunegala district, Sri Lanka.
TLDR
The results of this study provided the true burden of β thalassaemia trait and Hb E thalassemia in Kurunegala district.
NESTROFT—A Cost-Effective Mass Screening Tool for the Detection of β-Thalassemia Carrier Status in Anemic Pregnant Women: A Step Toward Reducing the National Disease Burden
TLDR
Naked Eye Single Tube Red Cell Osmotic Fragility Test (NESTROFT) can be used as a simple and cost-effective mass screening tool for the detection of carrier status.
An Incidence of β-Thalassemia in South India – A Review
TLDR
Much more work is to be done in South India to know more about -Thalassemia and to bring awareness among the people.
Spectrum of Haemoglobinopathies in Sikh population of Bangalore: A pilot study
TLDR
Proper screening camps and counselling needs to be done on the population at risk about awareness and detection of heterozygous carriers; to prevent the birth of homozygous Beta Thalassemia Major Child.
STUDY THE LEVEL OF AWARENESS AMONG SINDHI FAMILIES OF DURG, CHHATTISGARH (INDIA): A QUESTIONNAIRE BASED STATISTICAL STUDY
TLDR
The knowledge level among Sindhi families is very poor about Thalassemia disease (TD) and various prevention policies are must be organized to increase their knowledge about ThAlassemic children's survival capability.
Role of Prothrombin time International normalized ratio and activated partial thromboplastin time in beta thalassemia major: A cross sectional study
TLDR
Significant alterations in PT / INR and APTT exist in beta thalassemia major patients and additional parameters and a tailored approach is suggested.
...
1
2
...

References

SHOWING 1-10 OF 31 REFERENCES
α-Thalassemia Among Tribal Populations of Eastern India
TLDR
Coexistence of α- and β-globin gene abnormalities was observed in up to 18% of some tribal groups, and the high inbreeding rate and lack of appropriate medical care make these populations particularly vulnerable.
Alpha-thalassemia among tribal populations of Eastern India.
TLDR
Coexistence of alpha- and beta-globin gene abnormalities was observed in up to 18% of some tribal groups, and the high inbreeding rate and lack of appropriate medical care make these populations particularly vulnerable.
Spectrum of hemoglobinopathies in the state of Orissa, India: a ten years cohort study.
  • R. S. Balgir
  • Medicine
    The Journal of the Association of Physicians of India
  • 2005
TLDR
The heterogeneous population is harbouring almost all major hemoglobinopathies in general castes, scheduled castes and tribes, belonging to Coastal and South-Western regions of Orissa.
Spectrum of hemoglobinopathies in the state of Orissa, India: a ten years cohort study.
TLDR
The heterogeneous population is harbouring almost all major hemoglobinopathies in general castes, scheduled castes and tribes, belonging to Coastal and South-Western regions of Orissa.
NESTROFF as a screening test for detection of Beta-thalassemia trait.
TLDR
The NESTROFT test proved to be simple, cheap easy to perform and adaptable for mass screening coming close to an ideal screening test for beta-Thalassemia trait.
Cord blood analysis for prenatal diagnosis of thalassemia major and hemophilia A.
TLDR
High performance liquid chromatography and factor VIII assay in cord blood are feasible alternatives for PND in Beta thalassemia and hemophilia A respectively, especially when DNA analysis is uninformative or there are financial constraints.
Validity of Nestroft in screening and diagnosis of beta-thalassemia trait.
TLDR
Comparative analysis of 'nestroft' with red cell indices, i.e. MCV and RBC count revealed it to be the most sensitive and specific test.
'NESTROFT'--an effective screening test for beta thalassemia trait.
TLDR
Naked Eye Single Tube Red Cell Osmotic Fragility Test is a sensitive, cost effective, rapid and reliable screening test for detection of beta thalassemia trait in a population.
Evaluation of naked eye single tube red cell osmotic fragility test in detecting beta-thalassemia trait.
TLDR
The Naked Eye Single Tube Red Cell Osmotic Fragility Test proved to be simple, cheap, easy to perform and adaptable for field surveys, coming close to an ideal screening test for beta-thalassemia minor.
NESTROFT as a screening test for the detection of thalassaemia & common haemoglobinopathies--an evaluation against a high performance liquid chromatographic method.
TLDR
Naked Eye Single Tube Red Cell Osmotic Fragility Test is a suitable test for screening for beta-thalassaemia and the common haemoglobinopathies seen in India and it is easy to perform, simple, inexpensive and does not require sophisticated equipment.
...
1
2
3
4
...