Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme.

@article{Park2006PrevalenceIT,
  title={Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme.},
  author={Chi Hye Park and Ari A Robicsek and George A. Jacoby and Daniel F. Sahm and David C. Hooper},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 11},
  pages={3953-5}
}
Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of >/=0.25 microg/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes. 
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