Prevalence gradients of Friedreich's Ataxia and R1b haplotype in Europe co‐localize, suggesting a common Palaeolithic origin in the Franco‐Cantabrian ice age refuge

@article{Vankan2013PrevalenceGO,
  title={Prevalence gradients of Friedreich's Ataxia and R1b haplotype in Europe co‐localize, suggesting a common Palaeolithic origin in the Franco‐Cantabrian ice age refuge},
  author={P. Vankan},
  journal={Journal of Neurochemistry},
  year={2013},
  volume={126},
  pages={11 - 20}
}
  • P. Vankan
  • Published 2013
  • Biology, Medicine
  • Journal of Neurochemistry
Combining data from epidemiological studies in Friedreich's Ataxia (FRDA) and patient organization membership lists, shows that FRDA prevalence exhibits large regional differences in Europe with a prevalence gradient from west to east. Highest levels are observed in northern Spain, south of France and Ireland, lowest levels in Scandinavia and Russia. The observed distribution of FRDA in Europe co‐localizes with the gradient of the chromosomal R1b marker as detected within west Europe. This… Expand
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