Prevalence and significance of naturally occurring mutations in the surface and polymerase genes of hepatitis B virus.

@article{Ogura1999PrevalenceAS,
  title={Prevalence and significance of naturally occurring mutations in the surface and polymerase genes of hepatitis B virus.},
  author={Yukie Ogura and Masayuki Kurosaki and Yasuhiro Asahina and Nobuyuki Enomoto and Fumiaki Marumo and Chifumi Sato},
  journal={The Journal of infectious diseases},
  year={1999},
  volume={180 5},
  pages={1444-51}
}
The prevalence and clinical significance of naturally occurring mutations in the full-length surface and overlapping polymerase genes of hepatitis B virus (HBV) were analyzed in 42 patients with chronic hepatitis. Mutations were observed in 10 patients (24%) in the a determinant region, which is the neutralizing epitope within the major hydrophilic region of the surface gene. A high proportion of these mutations (17/18; 94%) occurred in the first loop, unlike mutations induced by immunization… CONTINUE READING

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