Prevalence and progression of mitochondrial diseases: a study of 50 patients.

  title={Prevalence and progression of mitochondrial diseases: a study of 50 patients.},
  author={Javier Arpa and Antonio Cruz-Mart{\'i}nez and Yolanda Campos and Manuel Guti{\'e}rrez-Molina and Francisco Garc{\'i}a-R{\'i}o and Concepci{\'o}n P{\'e}rez-Conde and Miguel Angel Mart{\'i}n and Juan C. Rubio and Pilar del Hoyo and Ana Arpa-Fern{\'a}ndez and J. Olier Arenas},
  journal={Muscle & nerve},
  volume={28 6},
We report 50 patients with various clinical phenotypes of mitochondrial disease studied over the past 10 years in a large urban area (Madrid Health Area 5). The clinical phenotypes showed a large variety of abnormalities in molecular biology and biochemistry. The prevalence of mitochondrial diseases was found to be 5.7 per 100,000 in the population over 14 years of age. Clinical and electrophysiological assessment reveal signs of neuropathy in 10 patients. Electromyographic findings consistent… CONTINUE READING