Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study

@article{Visser2009PrevalenceAP,
  title={Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study},
  author={Pieter Jelle Visser and Frans R J Verhey and Dirk L. Knol and Philip Scheltens and Lars-Olof Wahlund and Yvonne Freund-Levi and Magda Tsolaki and Lennart Minthon and {\AA}sa K. Wallin and Harald Hampel and K. Buerger and Tuula A. Pirttila and Hilkka Soininen and Marcel G. M. Olde Rikkert and Marcel M Verbeek and Luiza Spiru and Kaj Blennow},
  journal={The Lancet Neurology},
  year={2009},
  volume={8},
  pages={619-627}
}
BACKGROUND Alzheimer's disease (AD) pathology is common in patients with amnestic mild cognitive impairment (aMCI) without dementia, but the prevalence of AD pathology in patients with subjective cognitive impairment (SCI) and non-amnestic mild cognitive impairment (naMCI) is unknown. AD is characterised by decreased CSF concentrations of Abeta(42) and increased concentrations of tau. We investigated the prevalence of a CSF AD profile in patients with SCI, naMCI, or aMCI and the association of… CONTINUE READING
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