Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms.

@article{Thoennissen2010PrevalenceAP,
  title={Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms.},
  author={Nils H. Thoennissen and Utz Krug and Dhong Hyun Tony Lee and Norihiko Kawamata and Gabriela B. Iwanski and Terra L. Lasho and Tamara Weiss and Daniel Nowak and Maya Koren-Michowitz and Motohiro Kato and Masashi Sanada and Lee-Yung Shih and Arnon Nagler and Sophie D Raynaud and Carsten M{\"u}ller-Tidow and Ruben A. Mesa and Torsten Haferlach and Dwight Gary Gilliland and Ayalew Tefferi and Seishi Ogawa and H Phillip Koeffler},
  journal={Blood},
  year={2010},
  volume={115 14},
  pages={2882-90}
}
Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia, and primary myelofibrosis show an inherent tendency for transformation into leukemia (MPN-blast phase), which is hypothesized to be accompanied by acquisition of additional genomic lesions. We, therefore, examined chromosomal abnormalities by high-resolution single nucleotide polymorphism (SNP) array in 88 MPN patients, as well as 71 cases with MPN-blast phase, and… CONTINUE READING
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