Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).

@article{Thiede2006PrevalenceAP,
  title={Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).},
  author={Christian Thiede and Sina Koch and Eva Creutzig and Christine Steudel and Thomas Illmer and Markus Schaich and Gerhard Ehninger},
  journal={Blood},
  year={2006},
  volume={107 10},
  pages={4011-20}
}
Mutations of the nucleophosmin (NPM1) gene have recently been described in patients with acute myeloid leukemia (AML). To clarify the prevalence as well as the clinical impact of this mutation, we investigated 1485 patients with AML for NPM1 exon 12 mutations using fragment analysis. A 4 bp insert was detected in 408 of 1485 patients (27.5%). Sequence analysis revealed known mutations (type A, B, and D) as well as 13 novel alterations in 229 analyzed cases. NPM1 mutations were most prevalent in… CONTINUE READING
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