Prevalence and natural history of pain in adults with multiple sclerosis: Systematic review and meta-analysis

@article{Foley2013PrevalenceAN,
  title={Prevalence and natural history of pain in adults with multiple sclerosis: Systematic review and meta-analysis},
  author={Peter Foley and Hanna M Vesterinen and Barry J A Laird and Emily S. Sena and Lesley Colvin and Siddharthan Chandran and Malcolm Robert Macleod and Marie Fallon},
  journal={PAIN{\textregistered}},
  year={2013},
  volume={154},
  pages={632-642}
}
The prevalence, associations, and natural history of pain in multiple sclerosis (MS) are poorly understood. The objective of this work was to study the prevalence of pain syndromes in MS both cross‐sectionally, and longitudinally during the MS disease course. We systematically identified prospective studies detailing pain prevalence in definite MS. We used pooled prevalence estimates, explored heterogeneity using meta‐regression, and analysed prevalence during the disease course using both… Expand

Paper Mentions

Interventional Clinical Trial
Chronic pain is one of the most prevalent, disabling and persistent symptoms affecting people with multiple sclerosis (MS). Different nonpharmacological treatments are known to be… Expand
ConditionsMultiple Sclerosis
InterventionBehavioral
Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study.
TLDR
Pain of any type seems to be much more frequent than NP in early nonprogressive MS, and the close relationship between pain, fatigue, and depression in MS should be considered for treatment decisions and future research on a possible common pathophysiology. Expand
Systematic assessment and characterization of chronic pain in multiple sclerosis patients
TLDR
The present study supports the routine assessment of neuropathic pain in MS patients, especially in those with a sensory functional system involvement, in order to avoid underdiagnosing and undertreating a potentially disabling condition. Expand
Towards a better understanding of MS pain: a systematic review of potentially modifiable psychosocial factors.
TLDR
A preliminary model of MS pain outlining specific psychosocial factors is presented with a conceptual formulation from both traditional, and contextual, cognitive-behavioural perspectives. Expand
The prevalence, characteristics and impact of chronic pain in people with muscular dystrophies: A systematic review and meta-analysis.
TLDR
How common chronic pain is across various MD populations is demonstrated and highlights the need for better recognition and understanding of the nature and impact of pain from health professionals. Expand
Prevalence of neuropathic pain in early multiple sclerosis
Background: Pain is considered a frequent symptom in multiple sclerosis. Neuropathic pain is the type of pain most closely related to the pathology of multiple sclerosis and its prevalence estimatesExpand
Identifying neuropathic pain in patients with multiple sclerosis: a cross-sectional multicenter study using highly specific criteria
TLDR
Investigating the prevalence of pain in MS using highly specific criteria for distinguishing the different types of pain showed that pain was associated with age, gender and disease severity and that neuropathic pain was distinctly associated with EDSS. Expand
Comorbidity is associated with pain-related activity limitations in multiple sclerosis.
TLDR
Comorbidity is associated with pain in persons with MS and closer examination of these associations may provide guidance for better management of this disabling symptom in MS. Expand
Chronic pain in multiple sclerosis: Is there also fibromyalgia? An observational study
  • A. Clemenzi, A. Pompa, +4 authors M. Grasso
  • Medicine
  • Medical science monitor : international medical journal of experimental and clinical research
  • 2014
TLDR
A high prevalence of chronic pain is found in persons with multiple sclerosis, with those patients displaying a higher disability and a more severe depression, and FM frequency, significantly higher than that observed in the general population, was detected among the MS patients with chronic pain. Expand
Pain in Multiple Sclerosis: Prevalence and Characteristics of Various Pain Conditions
TLDR
The heterogenity of pain experienced in MS, the capacity to experience more than one type of pain simultaneously and inadequate pain treatment are confirmed, confirming pain is an important therapeutic target in MS. Expand
Effectiveness of Exercise Interventions for Pain Reduction in People With Multiple Sclerosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
TLDR
The first systematic review of the effect of exercise interventions on pain in people with multiple sclerosis found some evidence that exercise compared with passive control alleviates pain in this population, but there were limitations in reporting and study quality. Expand
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