Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience.

@article{Qin2008PrevalenceAM,
  title={Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience.},
  author={X. W. Qin and Danielle M. Zerr and Scott J. Weissman and Janet A Englund and Donna M. Denno and Eileen J. Klein and Phillip I Tarr and Justin Kwong and Jennifer R Stapp and Luis G Tulloch and Emmanouil Galanakis},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 11},
  pages={3909-14}
}
The objective of this study was to investigate the trends and patterns of resistance in beta-lactamase-producing members of the family Enterobacteriaceae in a children's hospital over a 9-year period (1999 to 2007). Clinically significant isolates of the Enterobacteriaceae were screened for patterns of broad-spectrum resistance to beta-lactams. The strains likely to be resistant were subsequently confirmed by an inhibitor-based disc test. The plasmid-mediated resistance determinants in these… CONTINUE READING

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First report of the emergence of CTX-M-type extended-spectrum -lactamases (ESBLs) as the predominant ESBL isolated in a U.S. health care system

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