Prevalence and functional significance of thyrotropin receptor blocking antibodies in children and adolescents with chronic lymphocytic thyroiditis.

@article{Feingold2009PrevalenceAF,
  title={Prevalence and functional significance of thyrotropin receptor blocking antibodies in children and adolescents with chronic lymphocytic thyroiditis.},
  author={Shiri B. Feingold and Jessica R. Smith and Jeffrey Houtz and Erica Y. Popovsky and Rosalind S. Brown},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2009},
  volume={94 12},
  pages={
          4742-8
        }
}
CONTEXT TSH receptor (TSHR) blocking antibodies (Abs) inhibit TSH-induced thyroid growth and function in some adults with chronic lymphocytic thyroiditis (CLT), but their role in the pediatric age range is unknown. OBJECTIVES Our objectives were: 1) to determine the prevalence of TSHR blocking Abs in children and adolescents with CLT and 2) assess their functional significance both in vivo and in vitro. DESIGN AND SETTING This was a retrospective study in a referral outpatient setting… 
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Functional TSH receptor antibodies in children with autoimmune thyroid diseases
TLDR
Investigating the prevalence of TSHR-Ab in a paediatric cohort with AITD and healthy controls found that TSI is prevalent in children with GD while the highest serum TSI levels were noted inChildren with A ITD and orbitopathy.
Investigation of TSH receptor blocking antibodies in childhood-onset atrophic autoimmune thyroiditis
  • K. Nagasaki, A. Nakamura, +9 authors T. Tajima
  • Medicine, Biology
    Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology
  • 2021
TLDR
It was shown that the prevalence of TSBAb-positivity in childhood-onset AATs is not rare, as in adults, and there were no significant differences in age, the estimated time between onset and diagnosis, and FT4 levels at diagnosis between the TSBAB-positive and -negative groups.
Non-Conventional Clinical Uses of TSH Receptor Antibodies: The Case of Chronic Autoimmune Thyroiditis
TLDR
The routine use of anti-TSH receptor antibodies (either TRAb or TSAb/TBAb) assay cannot be suggested at the present for diagnosis/follow up of patients affected by CAT; there are, however, several conditions where their detection can be clinically relevant.
Functional diagnostics for thyrotropin hormone receptor autoantibodies: bioassays prevail over binding assays.
TLDR
A technical and analytical account of leading commercial diagnostic methods of anti-TSH-R antibodies, a metaanalysis of their clinical performance and a perspective for the use of cell based TSH-R bioassays in the clinical diagnostics of Graves' disease are presented.
Thyroid Stimulating Antibodies Are Highly Prevalent in Hashimoto's Thyroiditis and Associated Orbitopathy.
TLDR
There is evidence that TSH receptor stimulating antibodies (TSAb) play a role in the pathogenesis of TAO and TSAb may contribute to the pathophysiology ofTAO.
Clinical and Biochemical Characteristics of Severe Hypothyroidism Due to Autoimmune Thyroiditis in Children
TLDR
In children with severe hypothyroidism, the most sensitive symptoms are growth arrest and weight gain despite the fact that, in some children, the auxological parameters at presentation could be within normal values for the population.
Thyrotropin Receptor Blocking Antibodies
  • T. Diana, P. D. Olivo, G. Kahaly
  • Biology, Medicine
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2018
TLDR
The prevalence and functional significance of TSHR blocking autoantibodies (TBAb) in autoimmune hypothyroidism has been less well investigated compared to T SHR stimulating Ab, but there is an increasing body of data, however, that demonstrate the clinical utility and relevance of TBAb.
Autoimmune Thyroiditis in Childhood
  • Rosalind S. Brown
  • Medicine, Biology
    Journal of clinical research in pediatric endocrinology
  • 2013
TLDR
Antibodies to a variety of thyroid-specific antigens are detectable in a majority of patients, but the role of Abs in mediating cell injury and death is unclear and only thyrotropin (TSH) receptor Abs significantly affect thyroid function by interfering with (or stimulating) the action of TSH.
Bioassays for TSH-receptor autoantibodies: an update.
A novel bioassay for anti‐thyrotrophin receptor autoantibodies detects both thyroid‐blocking and stimulating activity
TLDR
This TBAb bioassay provides a useful tool for measuring the activity of anti‐TSHR antibodies and may help clinicians to characterize the diverse clinical presentations of patients with AITD.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
It is found that thyrotrophin-receptor-blocking antibodies play a pathogenic role in a group of patients with primary myxedema and transient hypothyroidism was seen in all 5 infants born to 4 mothers having potent inhibitor immunoglobulins.
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TLDR
Hypothyroidism in some patients with autoimmune thyroiditis may be due to thyrotropin-blocking antibodies, which may cause transient as well as permanent hypothyroidistan.
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TLDR
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