Prevalence and differentiation of hereditary breast and ovarian cancers in Japan.

@article{Nakamura2015PrevalenceAD,
  title={Prevalence and differentiation of hereditary breast and ovarian cancers in Japan.},
  author={Seigo Nakamura and Masato Takahashi and Mitsuhiro Tozaki and Takahiro Nakayama and Tadashi Nomizu and Yoshio Miki and Yoshie Murakami and Daisuke Aoki and Takuji Iwase and Seiichiro Nishimura and Hideko Yamauchi and Shozo Ohsumi and Shinichi Baba and Tadao Shimizu},
  journal={Breast cancer},
  year={2015},
  volume={22 5},
  pages={462-8}
}
BACKGROUND We assembled needed data on the prevalence and characteristics of BRCA1/2 in Japan. MATERIALS AND METHODS Our study of BRCA1/2 collected data at eight institutions in Japan on 320 individuals with a strong family history of breast cancer, according to the NCCN guidelines, by the end of March 2012. RESULTS Among 260 proband cases, 46 (17.7 %) were positive for BRCA1, and 35 (13.5 %) were BRCA2-positive. Therefore, the total pathological mutation rate was 30.7 %. Pathology data… CONTINUE READING
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