Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer.

@article{Iyer2013PrevalenceAC,
  title={Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer.},
  author={Gopa Iyer and Hikmat A. Al-Ahmadie and Nikolaus Schultz and Aphrothiti J. Hanrahan and Irina Ostrovnaya and Arjun V Balar and Philip H.-S. Kim and Oscar Lin and Nils Weinhold and Chris Sander and Emily C Zabor and Manickam Janakiraman and Ilana Rebecca Garcia-Grossman and Adriana Heguy and Agnes J. Viale and Bernard H. Bochner and Victor R. Reuter and Dean F Bajorin and Matthew Ivan Milowsky and Barry S. Taylor and David B. Solit},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2013},
  volume={31 25},
  pages={
          3133-40
        }
}
PURPOSE We sought to define the prevalence and co-occurrence of actionable genomic alterations in patients with high-grade bladder cancer to serve as a platform for therapeutic drug discovery. PATIENTS AND METHODS An integrative analysis of 97 high-grade bladder tumors was conducted to identify actionable drug targets, which are defined as genomic alterations that have been clinically validated in another cancer type (eg, BRAF mutation) or alterations for which a selective inhibitor of the… CONTINUE READING
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