Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes.

@article{Romero2014PrevalenceAC,
  title={Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes.},
  author={Roberto Romero and Jezid Miranda and Tinnakorn Chaiworapongsa and Steven J Korzeniewski and Piya Chaemsaithong and Francesca Gotsch and Zhong Dong and Ahmed Ahmed Ibrahim Ahmed and Bo Hyun Yoon and Sonia S. Hassan and Chong Jai Kim and Lami Yeo},
  journal={American journal of reproductive immunology},
  year={2014},
  volume={72 5},
  pages={458-74}
}
PROBLEM Inflammation and infection play a major role in preterm birth. The purpose of this study was to (i) determine the prevalence and clinical significance of sterile intra-amniotic inflammation and (ii) examine the relationship between amniotic fluid (AF) concentrations of high mobility group box-1 (HMGB1) and the interval from amniocentesis to delivery in patients with sterile intra-amniotic inflammation. METHOD OF STUDY AF samples obtained from 135 women with preterm labor and intact… CONTINUE READING
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