Prevalence and clinical relevance of local allergic rhinitis

  title={Prevalence and clinical relevance of local allergic rhinitis},
  author={Carmen Rond{\'o}n and Paloma Campo and Luisa Galindo and Natalia Blanca-L{\'o}pez and Maria Salas Cassinello and Jos{\'e} Luis Rodr{\'i}guez-Bada and M J Torres and Miguel Blanca},
Evidence demonstrates the existence of local allergic rhinitis (LAR) in nonatopic patients, although its prevalence in the rhinitis population remains unknown. The aim, therefore, of this study was to evaluate the prevalence, clinical characteristics, and severity of LAR in a Spanish rhinitis population, compared with patients having classical allergic rhinitis (AR) with systemic atopy or nonallergic rhinitis (NAR). 

Local Allergic Rhinitis.

Detection of local allergic rhinitis in children with chronic, difficult‐to‐treat, non‐allergic rhinitis using multiple nasal provocation tests

The aim was to determine the proportion of children with LAR amongst children with chronic, difficult‐to‐treat, perennial or seasonal, rhinitis but no evidence of sensitization to aeroallergens, or other alternative diagnosis.

Current Update of Local Allergic Rhinitis

Effectiveness and safety of allergen immunotherapy open a window of treatment opportunity in LAR, and a current update on LAR is provided.

The importance of mold sensitivity in nonallergic rhinitis patients

The aim of this study was to evaluate the presence of local allergic rhinitis (LAR) in patients who experiencerhinitis symptoms in indoor and outdoor moldy conditions and to investigate the role of the NAPT in diagnosis.

Positive allergen reaction in allergic and nonallergic rhinitis: a systematic review

The objective of this study was to determine the frequency of nasal reactivity toward allergens among AR and NAR patients, and to describe the diagnostic characteristics of NAPT methodologies.

Local allergic rhinitis is an independent rhinitis phenotype: The results of a 10‐year follow‐up study

The aim of this study was to prospectively evaluate the natural history of a population with LAR, the potential conversion to AR with systemic atopy and the development of asthma during 10 years.

The proportion of local allergic rhinitis to Dermatophagoides pteronyssinus in children

Local allergic rhinitis (LAR) is diagnosed by the positive response to nasal allergen provocation test (NAPT) to aeroallergen and/or local synthesis of specific IgE (sIgE). This entity is found in

New Findings in Nonallergic Rhinitis and Local Allergic Rhinitis

The new pathophysiology and clinical insights into these different forms of nonallergic rhinitis with special emphasis on local allergy are described and new recommendations in diagnosis and treatment are given.

Local Allergic Rhinitis Revisited

This review aims to comprehensively summarize the current knowledge on LAR and address unmet needs in the areas of disease diagnosis and treatment.

Evidences for Local Allergic Rhinitis

Local allergic rhinitis is defined as a localized allergic reaction of the nasal mucosa in the absence of systemic atopy. Its main pathophysiological mechanism can be summarized as: 1) increased



Atypical nasal challenges in patients with idiopathic rhinitis: more evidence for the existence of allergy in the absence of atopy?

This study compares detailed nasal challenge results obtained from patients with idiopathic rhinitis to those of atopic and normal controls.

Seasonal idiopathic rhinitis with local inflammatory response and specific IgE in absence of systemic response

N nasal mucosa inflammation, the presence of nasal specific‐IgE and the response to nasal allergen provocation test (NAPT) in patients with seasonal IR who presented symptoms only in spring are examined.

Evidence for an inflammatory pathophysiology in idiopathic rhinitis

This work has shown that persistent idiopathic rhinitis has a Th2 type inflammatory pathology mediated by IgE and mast cells, and the disease is classified as being non‐allergic on the basis of negative serum IgE radioallergosorbent assay (RAST) and skin prick tests.

‘Entopy’: localized mucosal allergic disease in the absence of systemic responses for atopy

The Th2 immune response in the nasal mucosa of subjects with allergic rhinitis is mediated by allergen‐specific IgE, and subjects with similar histological nasal mucosal features differ in being defined as non‐allergic because they have negative atopic responses.

Allergic Rhinitis and its Impact on Asthma (ARIA)

A new subdivision of allergic rhinitis is proposed and suggests evidence-based management of the disease using a stepwise approach and it is proposed that allergic patients are treated globally to combine treatment of upper and lower airway disease.

Differences between allergic and nonallergic rhinitis in a large sample of adolescents and adults

Differences between allergic rhinitis (AR) and nonallergic rhINitis (NAR) in a large community‐based sample of Danish adolescents and adults are described.

Immediate and dual response to nasal challenge with Dermatophagoides pteronyssinus in local allergic rhinitis

  • S. LópezC. Rondón M. Blanca
  • Medicine, Biology
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2010
Background Local allergic rhinitis (LAR) is characterized by in situ production of specific IgE (sIgE) antibodies and a positive response to a nasal allergen provocation test (NAPT) in the absence of

Relationships between rhinitis and asthma

Although the nasal and bronchial mucosa present similarities, there are also differences which might suggest that rhinitis and asthma are two different airway diseases.

Update on nonallergic rhinitis.

  • R. SettipaneP. Lieberman
  • Medicine
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2001