Prevalence and clinical characteristics of mitochondrial tRNA leu(UUR) mt 3243 A-->G and ND-1 gene mt 3316 G-->A mutations in Chinese patients with type 2 diabetes.

@article{Ji2001PrevalenceAC,
  title={Prevalence and clinical characteristics of mitochondrial tRNA leu(UUR) mt 3243 A-->G and ND-1 gene mt 3316 G-->A mutations in Chinese patients with type 2 diabetes.},
  author={Li Nong Ji and Xu-hong Hou and Xue-yao Han},
  journal={Chinese medical journal},
  year={2001},
  volume={114 11},
  pages={1205-7}
}
OBJECTIVE To assess the prevalence of mitochondrial tRNA leu(UUR) gene mt 3243 A-->G mutation and ND-1 gene mt 3316 G-->A mutation in Chinese type 2 diabetes. METHODS 716 randomly selected, unrelated patients with type 2 diabetes were screened for the mutation with a PCR-RFLP technique. RESULTS Three individuals with mitochondrial tRNA leu(UUR) gene mt 3243 A-->G mutation were identified, representing approximately 0.4% of the type 2 patients screened. Further screening of first-degree… CONTINUE READING

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