Prevalence and changes in hepatitis C virus genotypes among multitransfused persons with hemophilia. The Multicenter Hemophilia Cohort Study.

@article{Eyster1999PrevalenceAC,
  title={Prevalence and changes in hepatitis C virus genotypes among multitransfused persons with hemophilia. The Multicenter Hemophilia Cohort Study.},
  author={M. Elaine Eyster and Kenneth E Sherman and James Jerome Goedert and Antigoni Katsoulidou and Angelos Hatzakis},
  journal={The Journal of infectious diseases},
  year={1999},
  volume={179 5},
  pages={1062-9}
}
The purpose of this study was to determine hepatitis C virus (HCV) genotypes and their relationship to HCV RNA levels over time in a cohort of multitransfused hemophiliacs. Following reverse transcription and polymerase chain reaction amplification of HCV RNA, the product DNAs were genotyped by using the line probe assay. HCV RNA was quantified by the branched-chain DNA assay. Genotyping was done on 109 serum samples from 32 subjects. Genotype 3a had the highest prevalence (41%), followed by… CONTINUE READING