Prevalence and Drug Susceptibility of Pathogens Causing Bloodstream Infections in Northern Italy: A Two-Year Study in 16 Hospitals

@article{Luzzaro2002PrevalenceAD,
  title={Prevalence and Drug Susceptibility of Pathogens Causing Bloodstream Infections in Northern Italy: A Two-Year Study in 16 Hospitals},
  author={Francesco Luzzaro and E F Vigan{\`o} and Daniela Fossati and Adriano Grossi and A. Sala and C. Sturla and Mariella Saudelli and Antonio Toniolo and Amcli Lombardia Hospital Infections Study Group},
  journal={European Journal of Clinical Microbiology and Infectious Diseases},
  year={2002},
  volume={21},
  pages={849-855}
}
Abstract. [] Key Result Overall, 2,924 microorganisms causing significant bacteremia were collected. The most frequent isolates were Escherichia coli (n=663; 22.7%), Staphylococcus aureus (n=534; 18.3%), Staphylococcus epidermidis (n=242; 8.2%), and Pseudomonas aeruginosa (n=176; 6.0%). Unlike Escherichia coli, which was usually acquired from the community, Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa were usually acquired in hospitals.
View on Springer
ncbi.nlm.nih.gov
79 Citations
Highly Influential Citations
6
Background Citations
20
Methods Citations
2
Results Citations
6

79 Citations

Bacterial Isolates from Severe Infections and Their Antibiotic Susceptibility Patterns in Italy: a Nationwide Study in the Hospital Setting
TLDR
The results obtained in this study, the first of its kind in Italy, offer indications for guiding empirical therapy and implementing specific interventions to fight antibiotic-resistant bacterial infections and their transmission in the hospital setting in Italy.
Prevalence and epidemiology of microbial pathogens causing bloodstream infections: results of the OASIS multicenter study.
Occurrence and antimicrobial resistance pattern comparisons among bloodstream infection isolates from the SENTRY Antimicrobial Surveillance Program (1997-2002).
Frequency and antimicrobial resistance of gram-positive bacterial pathogens from bloodstream infections in the Czech Republic
TLDR
Staphylococci, pneumococci and enterococci are presently the most common grampositive organisms causing BSIs in the Czech Republic, which corresponds with the results of other reports.
Pathogens constancy, harbinger of nosocomial infection cum identification of resistant genes and drug designing
Antibiotic resistance of blood cultures in regional and tertiary hospital settings of Tyrol, Austria (2006-2015): Impacts & trends
TLDR
The incidence of BSI in TH was higher compared to PH and higher contamination rates in the TH, and separate treatment guidelines for BSI by hospital setting are recommended.
Hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) in Italy
TLDR
The alternation of MRSA clones that occurred in hospitals from 1990 to 2007 and the increase of the glycopeptide MIC levels, reflecting a worldwide trend are described.
Distribution of Classes 1 and 2 Integrons among Multi Drug Resistant E. coli Isolated from Hospitalized Patients with Urinary Tract Infection in Cairo, Egypt
TLDR
The strong association observed between plasmid profiles and drug resistance patterns suggest that plasmids have epidemiological significance and could be used for initial therapy for MDR E. coli mediated UTIs.
Trends in Methicillin-Resistant Staphylococcus aureus (MRSA) Bloodstream Infections: Effect of the MRSA “Search and Isolate” Strategy in a Hospital in Italy with Hyperendemic MRSA
TLDR
A reduction in MRSA bacteremia is achievable through use of the MRSA “search and isolate” intervention even in a hospital with high rates of endemic MRSA.
Epidemiological study of nosocomial bacteremia in Al-Najaf Al-Ashraf
TLDR
This study was performed to identify patients who had nosocomial bacteramia and identify the pathogen responsible and its resisitance to antibiotics and to identify the organisms causing bacteremia and also their sensitivity to antibiotics.
...
...

References

SHOWING 1-10 OF 27 REFERENCES
Antimicrobial susceptibility and frequency of occurrence of clinical blood isolates in Europe from the SENTRY antimicrobial surveillance program, 1997 and 1998.
TLDR
The incidence of vancomycin resistance in enterococci was relatively low overall and primarily associated with Enterococcus faecium, but extrapolation of these data to smaller and nonteaching hospitals should be undertaken with caution, since resistance rates may be lower in these facilities.
Bacterial Pathogens Isolated from Patients with Bloodstream Infection: Frequencies of Occurrence and Antimicrobial Susceptibility Patterns from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 1997)
TLDR
Overall, U.S. isolates were considerably more resistant than those from Canada, and distinct differences were noted in the antimicrobial susceptibilities of several pathogens.
Incidence of antibiotic resistance in blood and urine isolates from hospitalized patients. Report from a European collaborative study. European Study Group on Antibiotic Resistance (ESGAR).
TLDR
The prevalence of MRSA was significant in central and southern Europe and the resistance rates to beta-lactam antibiotics among the gram-negatives have not changed except with an increase to cefotaxime and ceftazidime in central Europe.
The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults.
  • M. Weinstein, M. Towns, L. Reller
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1997
TLDR
Bloodstream infections in the 1990s are notable for the increased importance of CNS as both contaminants and pathogens, the proportionate increase in fungi and decrease in anaerobes as pathogens,The emergence of Mycobacterium avium complex as an important cause of bacteremia in patients with advanced human immunodeficiency virus infection, and the reduction in mortality associated with infection.
Dynamics of a Nosocomial Outbreak of Multidrug-Resistant Pseudomonas aeruginosa Producing the PER-1 Extended-Spectrum β-Lactamase
TLDR
The report indicates that theblaPER-1 resistance determinant may become an emerging therapeutic problem in Europe.
Nosocomial bloodstream infections: organisms, risk factors, and implications.
  • A. Karchmer
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2000
In the last 30 years, the frequency, etiology, and epidemiology of bloodstream infections (BSIs) have changed with the evolution of medical care, particularly among the increasing number of…
Widespread detection of PER-1-type extended-spectrum beta-lactamases among nosocomial Acinetobacter and Pseudomonas aeruginosa isolates in Turkey: a nationwide multicenter study
TLDR
Per-1-type-beta-lactamase-positive isolates appear to be restricted to Turkey, however, their clonal diversity and high prevalence indicate a high spreading potential.
A 25-year study of nosocomial bacteremia in an adult intensive care unit.
TLDR
Bacteremias have become more frequent in the ICU, probably because of the increased use of intravascular catheters, which are the most frequent foci for bacteremic infection.
Report of ESGNI–001 and ESGNI–002 studies. Bloodstream infections in Europe
TLDR
When EU and non-EU countries were compared there were no significant differences in the clinical data, reported between both groups, and the multivariable analysis showed that the factors remaining independent predictors of mortality were age, severity of underlying diseases and severity of sepsis score.
Carbapenem-resistant Pseudomonas aeruginosa with acquired bla(vim) metallo-beta-lactamase determinants, Italy.
TLDR
Although completely unrelated at the sequence level, blaVIM resembles blaIMP in being carried on an integron-borne mobile gene cassette and in encoding an enzyme (VIM-1) with broad substrate specificity, and has the potential to become a dangerous resistance determinant.
...
...