Prevalence and Characteristics of Subjective Akathisia, Objective Akathisia, and Mixed Akathisia in Chronic Schizophrenic Subjects

  title={Prevalence and Characteristics of Subjective Akathisia, Objective Akathisia, and Mixed Akathisia in Chronic Schizophrenic Subjects},
  author={Jong‐Hoon Kim and Heejung Byun},
  journal={Clinical Neuropharmacology},
Akathisia is a complex syndrome that is characterized by subjective inner restlessness and objective motor manifestations, and it can be classified into several subtypes. The purpose of this study was to examine the prevalence of subjective akathisia, objective akathisia, and mixed akathisia, and to evaluate their relationships with other drug-induced movement disorders, in chronic schizophrenic subjects treated with antipsychotics. One hundred and forty-two in-patients were assessed for… 

Multidimensional Sensory Phenomena in Antipsychotic-Induced Akathisia

The results of the present study suggest that the sensory phenomena of antipsychotic-induced akathisia are characterized by multidimensional features such as bodily sensations, mental sensations, and several autonomic sensations.

Case Report: Changes in Regional Cerebral Blood Flow in Chronic Akathisia of a Depressed Patient Before and After Electroconvulsive Therapy Treatment

ECT is suggested as a beneficial treatment for chronic akathisia and altered rCBF in the middle frontal gyrus, parietal lobe, thalamus, fusiform Gyrus, and cerebellum, and especially decreased rCBf in the parietal frontal lobe, may be related to the pathophysiology of chronic akATHisia.

Vitamin B6 Versus Mianserin and Placebo in Acute Neuroleptic-induced Akathisia: A Randomized, Double-blind, Controlled Study

The results indicate that high doses of B6 and a low dose of mianserin may be a useful addition to current treatments of NIA and suggests that the pathophysiology of acute NIA is heterogeneous with the various subtypes of acuteNIA responding differently to the various pharmacological approaches.

Liverpool University Neuroleptic Side‐Effect Rating Scale (LUNSERS) as a subjective measure of drug‐induced parkinsonism and akathisia

The results suggest that the EPS and psychic side‐effect subscales of LUNSERS may be useful in screening for drug‐induced parkinsonism and akathisia.

Trazodone for the Treatment of Neuroleptic-Induced Acute Akathisia: A Placebo-Controlled, Double-Blind, Crossover Study

It is suggested that Trz's property of serotonin 2A postsynaptic receptor antagonism may be its principal mechanism for the improvement of NIA.

Vitamin B6 treatment in acute neuroleptic-induced akathisia: a randomized, double-blind, placebo-controlled study.

Preliminary results indicate that high doses of vitamin B6 may be useful additions to the available treatments for NIA, perhaps due to its combined effects on various neurotransmitter systems.

Drug-induced parkinsonism.

Drug-induced tardive motor syndromes.

The aim of this article is to review the phenomenology, epidemiology and treatment options of the TMS, as clinically distinct movement disorders, as well as some specific Syndromes less often presented such as Pisa, Meige and Rabbit syndromes.

Altered heart rate dynamics associated with antipsychotic-induced subjective restlessness in patients with schizophrenia

It is indicated that antipsychotic-induced subjective restlessness is associated with altered heart rate dynamics parameters, particularly the nonlinear complexity measure, suggesting that it might adversely affect autonomic neurocardiac integrity.



Akathisia variants and tardive dyskinesia.

The findings suggested a possible relationship between pseudoakathisia, orofacial and limb dyskinesia, and the severity of negative schizophrenic symptoms.

Akathisia: Prevalence and Associated Dysphoria in an In-patient Population with Chronic Schizophrenia

The findings support the suggestion that dysphoric mood is an important feature of akathisia, and no significant relation was found between chronic akATHisia and tardive dyskinesia, although there was a trend for trunk and limb dyskine to be commonest in patients with chronic akath isia.

Clinical characteristics and predisposing factors in acute drug-induced akathisia.

The most significant predisposing factors were the extrapyramidal side effects score and current neuroleptic dose and its rate of increment, with lesser contributions from serum iron status and medication type.

Subjective emotional experience and cognitive impairment in drug-induced akathisia.

It is suggested that akathisia is significantly associated with depressive symptoms and attentional impairment, which reflects the complex nature of akath isia that includes motor, emotional, and cognitive aspects.

Akathisia in Parkinson's disease

  • C. ComellaC. Goetz
  • Medicine, Psychology
    Movement disorders : official journal of the Movement Disorder Society
  • 1994
The presence of akathisia was associated with the severity and age of onset of PD, and symptoms most frequently affected the legs, and associated movements were suppressible for brief periods.

Extrapyramidal syndromes in neuroleptic-treated patients: prevalence, risk factors, and association with tardive dyskinesia.

It is suggested that the association between EPS and TD may be limited to specific subtypes of TD, and peripheral TD showed a higher association with parkinsonism and with akathisia, suggesting that these symptoms may share a common pathophysiology.

Does akathisia influence psychopathology in psychotic patients treated with clozapine?

The Nithsdale Schizophrenia Surveys. IX: Akathisia, Parkinsonism, Tardive Dyskinesia and Plasma Neuroleptic Levels

Plasma neuroleptic levels at the time of clinical assessment were low; the ratio of mean plasma concentration to mean dose was greatest with fluphenazine decanoate and lowest for sulpiride, and the concentration:dose ratio was higher in the elderly.