Prevalence, virulence profiles, and clinical significance of Shiga toxin-negative variants of enterohemorrhagic Escherichia coli O157 infection in humans.

@article{Friedrich2007PrevalenceVP,
  title={Prevalence, virulence profiles, and clinical significance of Shiga toxin-negative variants of enterohemorrhagic Escherichia coli O157 infection in humans.},
  author={Alexander W. Friedrich and Wenlan Zhang and Martina Bielaszewska and Alexander Mellmann and Robin K{\"o}ck and Angelika Fruth and Helmut Tsch{\"a}pe and Helge Karch},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2007},
  volume={45 1},
  pages={
          39-45
        }
}
BACKGROUND Escherichia coli O157, of the H7 clone, exists in humans and in the environment as Shiga toxin (Stx)-positive and Stx-negative variants. Stx production by infecting organisms is considered to be a critical requirement for the development of hemolytic uremic syndrome (HUS), which occurs in approximately 15% of E. coli O157-infected patients. It is unknown if loss of the stx gene during the early stage of an enterohemorrhagic E. coli infection prevents HUS, or if absence of the stx… CONTINUE READING
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