Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents.

@article{Wlodarski2016PrevalenceCC,
  title={Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents.},
  author={M. Wlodarski and Shinsuke Hirabayashi and V. Pastor and J. Star{\'y} and H. Hasle and R. Masetti and M. Dworzak and M. Schmugge and M. M. van den Heuvel-Eibrink and M. Ussowicz and B. De Moerloose and A. Catal{\`a} and O. Smith and P. Sedl{\'a}cek and A. Lankester and M. Zecca and V. Bordon and S. Matthes-Martin and J. Abrahamsson and J. K{\"u}hl and K. Sykora and M. Albert and Bartlomiej Przychodzien and J. Maciejewski and S. Schwarz and G. G{\"o}hring and B. Schlegelberger and A. Cseh and P. N{\"o}llke and A. Yoshimi and F. Locatelli and I. Baumann and B. Strahm and C. Niemeyer},
  journal={Blood},
  year={2016},
  volume={127 11},
  pages={
          1387-97; quiz 1518
        }
}
  • M. Wlodarski, Shinsuke Hirabayashi, +31 authors C. Niemeyer
  • Published 2016
  • Medicine
  • Blood
  • Germline GATA2 mutations cause cellular deficiencies with high propensity for myeloid disease. [...] Key Method We investigated 426 children and adolescents with primary myelodysplastic syndrome (MDS) and 82 cases with secondary MDS enrolled in 2 consecutive prospective studies of the European Working Group of MDS in Childhood (EWOG-MDS) conducted in Germany over a period of 15 years. Germline GATA2 mutations accounted for 15% of advanced and 7% of all primary MDS cases, but were absent in children with MDS…Expand Abstract
    170 Citations
    [Clinical and molecular characteristics of GATA2 related pediatric primary myelodysplastic syndrome].
    Pediatric MDS: GATA screen the germline.
    • 4
    • PDF
    Myelodysplastic syndromes in children
    • 2
    The genomic landscape of pediatric myelodysplastic syndromes
    • 43
    • PDF
    GATA2 Related Conditions and Predisposition to Pediatric Myelodysplastic Syndromes
    • PDF
    Pediatric myelodysplastic syndromes
    • 1
    • PDF
    Myelodysplastic and myeloproliferative disorders of childhood.
    • H. Hasle
    • Medicine
    • Hematology. American Society of Hematology. Education Program
    • 2016
    • 30
    • PDF
    Prevalence of germline GATA2 and SAMD9/9L variants in paediatric haematological disorders with monosomy 7
    • 3

    References

    SHOWING 1-10 OF 46 REFERENCES
    Clinical effect of point mutations in myelodysplastic syndromes.
    • 1,176
    Advances in the prognostication and management of advanced MDS in children
    • 58
    Heritable GATA2 Mutations Associated with Familial Myelodysplastic Syndrome and Acute Myeloid Leukemia
    • 424
    Familial myelodysplasia and acute myeloid leukaemia – a review
    • 161
    • PDF
    Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome.
    • 81
    • PDF