Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism.

  title={Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism.},
  author={Sheerazed Boulkroun and Felix Beuschlein and G. Rossi and Jos{\'e}-Felipe Golib-Dzib and Evelyn Fischer and Laurence Amar and Paolo Mulatero and Beno{\^i}t Samson-Couterie and Stefanie Hahner and Marcus Quinkler and Francesco Fallo and Claudio Letizia and Bruno Allolio and Giulio Ceolotto and Maria Verena Cicala and Katharina M Lang and Herv{\'e} Pierre Lefebvre and Livia Lenzini and Carmela Maniero and Silvia Monticone and Maelle Perrocheau and Catia Pilon and P. -F. Plouin and Nada Rayes and Teresa Maria Seccia and Franco Veglio and Tracy Ann Williams and Laura Zinnamosca and Franco Mantero and Arndt Benecke and Xavier Jeunema{\^i}tre and Martin Reincke and Maria-Christina Zennaro},
  volume={59 3},
Primary aldosteronism is the most common form of secondary hypertension. Mutations in the KCNJ5 gene have been described recently in aldosterone-producing adenomas (APAs). The aim of this study was to investigate the prevalence of KCNJ5 mutations in unselected patients with primary aldosteronism and their clinical, biological and molecular correlates. KCNJ5 sequencing was performed on somatic (APA, n=380) and peripheral (APA, n=344; bilateral adrenal hyperplasia, n=174) DNA of patients with… CONTINUE READING
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