Prevalence, characteristics, and publication of discontinued randomized trials.

@article{Kasenda2014PrevalenceCA,
  title={Prevalence, characteristics, and publication of discontinued randomized trials.},
  author={Benjamin Kasenda and Erik von Elm and John You and Anette Bl{\"u}mle and Yuki Tomonaga and Ramon T Saccilotto and Alain Amstutz and Theresa Bengough and Joerg J Meerpohl and Mihaela Stegert and Kari A O Tikkinen and Ignacio Neumann and Alonso Carrasco-Labra and Markus Faulhaber and Sohail M. Mulla and Dominik Mertz and Elie A. Akl and Dirk Bassler and Jason Walter Busse and Ignacio Ferreira-Gonz{\'a}lez and François Lamontagne and Alain Nordmann and Viktoria Gloy and Heike Raatz and Lorenzo Moja and Rachel Rosenthal and Shanil Ebrahim and Stefan Schandelmaier and Sun Xin and Per Olav Vandvik and Bradley C. Johnston and Martin A. Walter and Bernard Burnand and Matthias Schwenkglenks and Lars G Hemkens and Heiner C. Bucher and Gordon H. Guyatt and Matthias Briel},
  journal={JAMA},
  year={2014},
  volume={311 10},
  pages={1045-51}
}
IMPORTANCE The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. The epidemiology of discontinued RCTs, however, remains unclear. OBJECTIVES To determine the prevalence, characteristics, and publication history of discontinued RCTs and to investigate factors associated with RCT discontinuation due to poor recruitment and with nonpublication. DESIGN AND SETTING Retrospective cohort of RCTs based on archived protocols… CONTINUE READING

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STOPIT-2 Study Group. Stopping randomized trials early for benefit and estimation of treatment effects

  • D Bassler, M Briel, VM Montori
  • 2010
1 Excerpt

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