Prevalence, characteristics, and publication of discontinued randomized trials.


IMPORTANCE The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. The epidemiology of discontinued RCTs, however, remains unclear. OBJECTIVES To determine the prevalence, characteristics, and publication history of discontinued RCTs and to investigate factors associated with RCT… (More)
DOI: 10.1001/jama.2014.1361


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