Pretubulysin, a potent and chemically accessible tubulysin precursor from Angiococcus disciformis.


Simplify, simplify, simplify! Pretubulysin (structure without the green substituents), a simplified tubulysin was prepared in the laboratory and also found in a natural myxobacterial source. This biosynthetic precursor of the tubulysins is not as active as tubulysins A and D but is still effective in picomolar concentrations against cancer cell lines. 
DOI: 10.1002/anie.200900406


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