• Corpus ID: 9541259

Pretrolatum is not comedogenic in rabbits or humans : A critical reappraisal of the rabbit ear assay and the concept of acne cosmetica

  title={Pretrolatum is not comedogenic in rabbits or humans : A critical reappraisal of the rabbit ear assay and the concept of acne cosmetica},
  author={Albert Montgomery Kligman and Accepted March},
  journal={Journal of the society of cosmetic chemists},
The objective was to find out whether petrolatum, previously reported to be comedogenic in the rabbit ear model, would worsen acne. Vaseline petrolatum jelly (Vaseline®, Chesebrough-Ponds) and Vaseline petrolatum jelly cream (Creamy Vaseline®, Chesebrough-Ponds) were applied to separate groups of ten acne patients each twice daily for eight weeks. No evidence of comedogenic potential was found by the follicular biopsy technique. Papulo-pustules significantly decreased in both groups. Greasiness… 

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