• Corpus ID: 9541259

Pretrolatum is not comedogenic in rabbits or humans : A critical reappraisal of the rabbit ear assay and the concept of acne cosmetica

@article{Kligman1996PretrolatumIN,
  title={Pretrolatum is not comedogenic in rabbits or humans : A critical reappraisal of the rabbit ear assay and the concept of acne cosmetica},
  author={Albert Montgomery Kligman and Accepted March},
  journal={Journal of the society of cosmetic chemists},
  year={1996},
  volume={47},
  pages={41-48}
}
The objective was to find out whether petrolatum, previously reported to be comedogenic in the rabbit ear model, would worsen acne. Vaseline petrolatum jelly (Vaseline®, Chesebrough-Ponds) and Vaseline petrolatum jelly cream (Creamy Vaseline®, Chesebrough-Ponds) were applied to separate groups of ten acne patients each twice daily for eight weeks. No evidence of comedogenic potential was found by the follicular biopsy technique. Papulo-pustules significantly decreased in both groups. Greasiness… 

Figures from this paper

Comedogenicity of Oils

Application of coconut oil, mustard oil or liquid paraffin to acne prone skin is not advisable in the authors' environmental conditions and there is no antibacterial property for any of these oils.

Evaluation of Triaz 10% Gel and Benzamycin in acne vulgaris

Over 3 months of therapy with twice-daily application, benzoyl peroxide special gel was at least comparable to benzoyL peroxide-erythromycin in reducing inflamed lesions, noninflamed lesions (open + closed comedones) and the total of these lesions.

Acne Cosmetica Revisited: A Case-Control Study Shows a Dose-Dependent Inverse Association between Overall Cosmetic Use and Post-Adolescent Acne

Overall cosmetic use was negatively associated with post-adolescent acne, and the term ‘acne cosmetica' is appropriate in the sense that some cosmetics may cause acne.

Advanced chemical peels: phenol-croton oil peel.

Use of Oil Red O Staining Method in Non-Comedogenic Test for Cosmetics

This data indicates that non-comedogenic acne grading using Ellead’s ELlead system results in positive results for acne prevention and self-confidence in women.

References

SHOWING 1-10 OF 12 REFERENCES

Improved Procedure for Assessing Acnegenicity (Comedogenicity) in the Rabbit Ear Model

This paper describes a method based on histopathologic evaluation of the ear skin of male rabbits, treated once daily for 3 weeks, to identify substances capable of creating follicular horny impactions (comedones).

Use of the rabbit ear model in evaluating the comedogenic potential of cosmetic ingredients

The external ear canal of the rabbit has been utilized to assess the comedogenic potential of ingredients used in the formulation of products applied to the skin, and the activity of several substances previously reported is reviewed.

Is the rabbit ear model, in its present state, prophetic of acnegenicity?

  • S. Frank
  • Biology, Medicine
    Journal of the American Academy of Dermatology
  • 1982

Comedogenicity and irritancy of commonly used ingredients in skin care products

By following the guidelines developed in this study, it is possible to formulate nonirritating, noncomedogenic moisturizers, sunscreens, hair pomades, cosmetics, and conditioners.

Comedogenicity testing of cosmetics.

Adult acne can occur from the use or perhaps incorrect removal of cosmetics, and cosmetic firms have adopted the use of the rabbit ear comedogenicity assay to ensure the safety and noncomedogenicity

Cosmetics Content and Function

In treating patients with acne, the dermatologist is often asked to recommend cosmetic products that will not exacerbate skin conditions, and Cosmetic products containing fewer potentially comedogenic ingredients are listed.

Determination of density of follicles on various regions of the face by cyanoacrylate biopsy: correlation with sebum output

The number of follicles on the forehead, cheek, chin and nose of 12 healthy adult white women was determined using cyanoacrylate follicular biopsies and there was no correlation between these two parameters.

The follicular biopsy.

The follicular biopsy is useful for studying the contents of sebaceous follicles in health and disease and can be examined histologically at the light or electron microscopic level.

DRUGS THAT ARE INEFFECTIVE IN THE TREATMENT OF ACNE VULGARIS

It is declared that the Philadelphia area is apparently an unfavourable place for evaluating acne therapies and the placebo eflfect is especially feeble in the environment of the University of Pennsylvania.