Corpus ID: 9541259

Pretrolatum is not comedogenic in rabbits or humans : A critical reappraisal of the rabbit ear assay and the concept of acne cosmetica

@article{Kligman1996PretrolatumIN,
  title={Pretrolatum is not comedogenic in rabbits or humans : A critical reappraisal of the rabbit ear assay and the concept of acne cosmetica},
  author={A. Kligman and A. March},
  journal={Journal of the society of cosmetic chemists},
  year={1996},
  volume={47},
  pages={41-48}
}
The objective was to find out whether petrolatum, previously reported to be comedogenic in the rabbit ear model, would worsen acne. Vaseline petrolatum jelly (Vaseline®, Chesebrough-Ponds) and Vaseline petrolatum jelly cream (Creamy Vaseline®, Chesebrough-Ponds) were applied to separate groups of ten acne patients each twice daily for eight weeks. No evidence of comedogenic potential was found by the follicular biopsy technique. Papulo-pustules significantly decreased in both groups. Greasiness… Expand

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References

SHOWING 1-10 OF 12 REFERENCES
Improved Procedure for Assessing Acnegenicity (Comedogenicity) in the Rabbit Ear Model
TLDR
This paper describes a method based on histopathologic evaluation of the ear skin of male rabbits, treated once daily for 3 weeks, to identify substances capable of creating follicular horny impactions (comedones). Expand
Use of the rabbit ear model in evaluating the comedogenic potential of cosmetic ingredients
TLDR
The external ear canal of the rabbit has been utilized to assess the comedogenic potential of ingredients used in the formulation of products applied to the skin, and the activity of several substances previously reported is reviewed. Expand
Is the rabbit ear model, in its present state, prophetic of acnegenicity?
  • S. Frank
  • Medicine
  • Journal of the American Academy of Dermatology
  • 1982
The rabbit ear model has been proposed as a useful bioassay to establish the comedogenic and acnegenic qualities of chemical compounds and finished products, pharmaceutical and cosmetic, for topicalExpand
Comedogenicity and irritancy of commonly used ingredients in skin care products
TLDR
By following the guidelines developed in this study, it is possible to formulate nonirritating, noncomedogenic moisturizers, sunscreens, hair pomades, cosmetics, and conditioners. Expand
DRUGS THAT ARE INEFFECTIVE IN THE TREATMENT OF ACNE VULGARIS
TLDR
It is declared that the Philadelphia area is apparently an unfavourable place for evaluating acne therapies and the placebo eflfect is especially feeble in the environment of the University of Pennsylvania. Expand
Comedogenicity testing of cosmetics.
Adult acne can occur from the use or perhaps incorrect removal of cosmetics, and cosmetic firms have adopted the use of the rabbit ear comedogenicity assay to ensure the safety and noncomedogenicityExpand
Effects of petrolatum on stratum corneum structure and function.
TLDR
VPJ neither forms nor acts like an epicutaneous impermeable membrane; instead, it permeates throughout the SC interstices, allowing normal barrier recovery despite its occlusive properties. Expand
Cosmetics Content and Function
TLDR
In treating patients with acne, the dermatologist is often asked to recommend cosmetic products that will not exacerbate skin conditions, and Cosmetic products containing fewer potentially comedogenic ingredients are listed. Expand
Determination of density of follicles on various regions of the face by cyanoacrylate biopsy: correlation with sebum output
TLDR
The number of follicles on the forehead, cheek, chin and nose of 12 healthy adult white women was determined using cyanoacrylate follicular biopsies and there was no correlation between these two parameters. Expand
The follicular biopsy.
TLDR
The follicular biopsy is useful for studying the contents of sebaceous follicles in health and disease and can be examined histologically at the light or electron microscopic level. Expand
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