Pretreatment with soluble thrombomodulin prevents intrasinusoidal coagulation and liver dysfunction following extensive hepatectomy in cirrhotic rats.

@article{Kaido1999PretreatmentWS,
  title={Pretreatment with soluble thrombomodulin prevents intrasinusoidal coagulation and liver dysfunction following extensive hepatectomy in cirrhotic rats.},
  author={Toshimi Kaido and Aki Yoshikawa and Sinji Seto and Shoji Yamaoka and Hiroaki Furuyama and Shigeki Arii and Yukihiro Takahashi and Masahiro Imamura},
  journal={Thrombosis and haemostasis},
  year={1999},
  volume={82 4},
  pages={
          1302-6
        }
}
The major cause of posthepatectomy liver dysfunction is supposed to be microcirculatory disturbance caused by imbalance of intrasinusoidal coagulation equilibrium. Thrombomodulin (TM) is a potent anticoagulant expressed on the endothelial cell surface that regulates the coagulation system by binding thrombin and accelerating the thrombin-catalyzed activation of protein C. Therefore, we examined the effect of soluble TM purified from human urine (UTM) on intrasinusoidal coagulation in cirrhotic… CONTINUE READING