Pretreatment with simvastatin reduces lung injury related to intestinal ischemia-reperfusion in rats.

@article{Pirat2006PretreatmentWS,
  title={Pretreatment with simvastatin reduces lung injury related to intestinal ischemia-reperfusion in rats.},
  author={Arash Pirat and Pinar Zeyneloğlu and Derya Aldemir and Muammer Y{\"u}cel and Ozlem Isiksaçan Ozen and Selim Candan and G{\"u}lnaz Arslan},
  journal={Anesthesia and analgesia},
  year={2006},
  volume={102 1},
  pages={
          225-32
        }
}
In this rat model study we evaluated whether pretreatment with simvastatin affects the severity of acute lung injury caused by intestinal ischemia-reperfusion (I/R). Twenty-four animals were randomly allocated to three equal groups (sham, control, simvastatin). The simvastatin group was pretreated with simvastatin 10 mg x kg(-1) x day(-1) for 3 days, whereas the other groups received placebo. The simvastatin and control groups underwent 60 min of superior mesenteric artery occlusion and 90 min… CONTINUE READING

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