Pretreatment with sildenafil alleviates early lung ischemia-reperfusion injury in a rat model.

Abstract

BACKGROUND Lung ischemia-reperfusion (I/R) injury plays an important role in lung transplantation. Less well known is the role of sildenafil in lung I/R injury; therefore, we attempted to determine whether sildenafil could alleviate lung apoptosis and tissue injury in a rat model. METHODS Forty male Sprague-Dawley rats were randomized into four groups… (More)
DOI: 10.1016/j.jss.2013.07.010

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