Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced neurotoxicity.

@article{Ying2008PretreatmentWN,
  title={Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced neurotoxicity.},
  author={Rong Ying and Huan Ling Liang and Harry Thomas Whelan and Janis Thane Eells and Margaret T. T. Wong-Riley},
  journal={Brain research},
  year={2008},
  volume={1243},
  pages={167-73}
}
Parkinson's disease (PD) is a movement disorder caused by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to nigrostriatal degeneration. The inhibition of mitochondrial respiratory chain complex I and oxidative stress-induced damage have been implicated in the pathogenesis of PD. The present study used these specific mitochondrial complex I inhibitors (rotenone and 1-methyl-4-phenylpyridinium or MPP(+)) on striatal and cortical neurons in culture. The goal was to… CONTINUE READING
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